Seroatlas · Human Serome Atlas

STAC

SH3 and cysteine-rich domain-containing protein

Also known as: STAC_HUMAN, STAC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99469
Gene
STAC
Ensembl
ENSG00000144681
Chromosome
3
Canonical length
402 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Predicted to enable transmembrane transporter binding activity. Predicted to be involved in positive regulation of protein localization to plasma membrane; positive regulation of voltage-gated calcium channel activity; and skeletal muscle contraction. Predicted to act upstream of or within cellular response to heat; muscle contraction; and regulation of voltage-gated calcium channel activity. Predicted to be located in cytoplasmic side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>Q99469|STAC
     1  MIPPSSPRED GVDGLPKEAV GAEQPPSPAS TSSQESKLQK LKRSLSFKTK SLRSKSADNF
    61  FQRTNSEDMK LQAHMVAEIS PSSSPLPAPG SLTSTPARAG LHPGGKAHAF QEYIFKKPTF
   121  CDVCNHMIVG TNAKHGLRCK ACKMSIHHKC TDGLAPQRCM GKLPKGFRRY YSSPLLIHEQ
   181  FGCIKEVMPI ACGNKVDPVY ETLRFGTSLA QRTKKGSSGS GSDSPHRTST SDLVEVPEEA
   241  NGPGGGYDLR KRSNSVFTYP ENGTDDFRDP AKNINHQGSL SKDPLQMNTY VALYKFVPQE
   301  NEDLEMRPGD IITLLEDSNE DWWKGKIQDR IGFFPANFVQ RLQQNEKIFR CVRTFIGCKE
   361  QGQITLKENQ ICVSSEEEQD GFIRVLSGKK KGLIPLDVLE NI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STAC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 14 nTPM
  • prostate: 13 nTPM
  • lung: 10 nTPM
  • parathyroid gland: 9.4 nTPM
  • cerebellum: 6.8 nTPM
  • cervix: 6.6 nTPM

Single-cell type

  • corticotrophs: 503 nCPM
  • adrenal medulla cells: 202 nCPM
  • choroid plexus epithelial cells: 181 nCPM
  • müller glia: 170 nCPM
  • innate lymphoid cells: 146 nCPM
  • distal convoluted tubule cells: 110 nCPM

Immune cell

  • eosinophil: 1.5 nTPM
  • T-reg: 1.5 nTPM
  • NK-cell: 1.3 nTPM
  • intermediate monocyte: 0.2 nTPM
  • myeloid DC: 0.2 nTPM
  • memory CD4 T-cell: 0.1 nTPM

Brain region

  • pons: 15 nTPM
  • cerebral cortex: 11 nTPM
  • choroid plexus: 11 nTPM
  • hypothalamus: 8.8 nTPM
  • cerebellum: 7.4 nTPM
  • midbrain: 5.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0
gnomAD missense Z
0.3
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STAC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STAC as an antibody target. Whether an autoantibody or antibody against STAC could matter depends on whether native STAC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STAC is annotated at the cell surface, where native STAC is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label STAC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STAC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...