Seroatlas · Human Serome Atlas

STAC3

SH3 and cysteine-rich domain-containing protein 3

Also known as: MGC2793, STAC3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96MF2
Gene
STAC3
Ensembl
ENSG00000185482
Chromosome
12
Canonical length
364 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a component of the excitation-contraction coupling machinery of muscles. This protein is a member of the Stac gene family and contains an N-terminal cysteine-rich domain and two SH3 domains. Mutations in this gene are a cause of Native American myopathy. [provided by RefSeq, Nov 2013]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>Q96MF2|STAC3
     1  MTEKEVLESP KPSFPAETRQ SGLQRLKQLL RKGSTGTKEM ELPPEPQANG EAVGAGGGPI
    61  YYIYEEEEEE EEEEEEPPPE PPKLVNDKPH KFKDHFFKKP KFCDVCARMI VLNNKFGLRC
   121  KNCKTNIHEH CQSYVEMQRC FGKIPPGFHR AYSSPLYSNQ QYACVKDLSA ANRNDPVFET
   181  LRTGVIMANK ERKKGQADKK NPVAAMMEEE PESARPEEGK PQDGNPEGDK KAEKKTPDDK
   241  HKQPGFQQSH YFVALYRFKA LEKDDLDFPP GEKITVIDDS NEEWWRGKIG EKVGFFPPNF
   301  IIRVRAGERV HRVTRSFVGN REIGQITLKK DQIVVQKGDE AGGYVKVYTG RKVGLFPTDF
   361  LEEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STAC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
2,169 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 2,169 nTPM
  • tongue: 1,091 nTPM
  • salivary gland: 43 nTPM
  • esophagus: 29 nTPM
  • prostate: 22 nTPM
  • bone marrow: 17 nTPM

Single-cell type

  • myonuclei: 359 nCPM
  • thymic myoid cells: 303 nCPM
  • myosatellite cells: 56 nCPM
  • hofbauer cells: 46 nCPM
  • kupffer cells: 45 nCPM
  • megakaryocytes: 31 nCPM

Immune cell

  • intermediate monocyte: 5.8 nTPM
  • classical monocyte: 4.4 nTPM
  • myeloid DC: 3.6 nTPM
  • non-classical monocyte: 2.9 nTPM
  • total PBMC: 1.4 nTPM
  • plasmacytoid DC: 1 nTPM

Brain region

  • cerebellum: 6.6 nTPM
  • cerebral cortex: 4.1 nTPM
  • white matter: 3.3 nTPM
  • medulla oblongata: 2.8 nTPM
  • pons: 2.8 nTPM
  • amygdala: 2.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STAC3.

Disease | AllUniProt

Conditions STAC3 is implicated in, by any mechanism.

Disease | GeneticClinVar

15 pathogenic / likely-pathogenic of 304 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.75
gnomAD pLI
0
gnomAD missense Z
0.91
DepMap mean gene effect
-0.25
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STAC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STAC3 as an antibody target. Whether an autoantibody or antibody against STAC3 could matter depends on whether native STAC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STAC3 is annotated at the cell surface, where native STAC3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label STAC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STAC3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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