Seroatlas · Human Serome Atlas

STAC2

SH3 and cysteine-rich domain-containing protein 2

Also known as: 24b2, STAC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZMT1
Gene
STAC2
Ensembl
ENSG00000141750
Chromosome
17
Canonical length
411 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a protein containing an SH3 domain and a zinc finger domain. The encoded protein has been shown to regulate calcium channel inactivation in a human cell line. Reduced expression of this gene has been observed in human heart failure. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

411 residues, UniProt reviewed canonical sequence.

>Q6ZMT1|STAC2
     1  MTEMSEKENE PDDAATHSPP GTVSALQETK LQRFKRSLSL KTILRSKSLE NFFLRSGSEL
    61  KCPTEVLLTP PTPLPPPSPP PTASDRGLAT PSPSPCPVPR PLAALKPVRL HSFQEHVFKR
   121  ASPCELCHQL IVGNSKQGLR CKMCKVSVHL WCSEEISHQQ CPGKTSTSFR RNFSSPLLVH
   181  EPPPVCATSK ESPPTGDSGK VDPVYETLRY GTSLALMNRS SFSSTSESPT RSLSERDELT
   241  EDGEGSIRSS EEGPGDSASP VFTAPAESEG PGPEEKSPGQ QLPKATLRKD VGPMYSYVAL
   301  YKFLPQENND LALQPGDRIM LVDDSNEDWW KGKIGDRVGF FPANFVQRVR PGENVWRCCQ
   361  PFSGNKEQGY MSLKENQICV GVGRSKDADG FIRVSSGKKR GLVPVDALTE I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STAC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
112 nTPM

Expression across tissuesHPA

Tissue

  • retina: 112 nTPM
  • blood vessel: 79 nTPM
  • breast: 52 nTPM
  • skin: 49 nTPM
  • cerebral cortex: 46 nTPM
  • seminal vesicle: 22 nTPM

Single-cell type

  • müller glia: 960 nCPM
  • breast lactating cells: 209 nCPM
  • breast secretory cells: 183 nCPM
  • renal collecting duct intercalated cells: 132 nCPM
  • salivary myoepithelial cells: 131 nCPM
  • breast myoepithelial cells: 105 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 125 nTPM
  • white matter: 72 nTPM
  • pons: 66 nTPM
  • hypothalamus: 50 nTPM
  • midbrain: 40 nTPM
  • medulla oblongata: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STAC2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 79 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.95
gnomAD pLI
0
gnomAD missense Z
-0.1
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STAC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STAC2 as an antibody target. Whether an autoantibody or antibody against STAC2 could matter depends on whether native STAC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STAC2 is annotated at the cell surface, where native STAC2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label STAC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STAC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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