TNS1

Protein identityUniProt · HPA

UniProt accession

Q9HBL0

Gene

TNS1

Ensembl

ENSG00000079308

Chromosome

2

Canonical length

1839 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Focal adhesion sites

OverviewNCBI Gene

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Canonical amino-acid sequenceUniProt

1839 residues, UniProt reviewed canonical sequence.

>Q9HBL0|TNS1
     1  MTWICLSCML WPEDLEAPKT HRFKVKTFKK VKPCGICRQV ITQEGCTCKV CSFSCHRKCQ
    61  AKVAAPCVPP SNHELVPITT ENAPKNVVDK GEGASRGGNT RKSLEDNGST RVTPSVQPHL
   121  QPIRNMSVSR TMEDSCELDL VYVTERIIAV SFPSTANEEN FRSNLREVAQ MLKSKHGGNY
   181  LLFNLSERRP DITKLHAKVL EFGWPDLHTP ALEKICSICK AMDTWLNADP HNVVVLHNKG
   241  NRGRIGVVIA AYMHYSNISA SADQALDRFA MKRFYEDKIV PIGQPSQRRY VHYFSGLLSG
   301  SIKMNNKPLF LHHVIMHGIP NFESKGGCRP FLRIYQAMQP VYTSGIYNIP GDSQTSVCIT
   361  IEPGLLLKGD ILLKCYHKKF RSPARDVIFR VQFHTCAIHD LGVVFGKEDL DDAFKDDRFP
   421  EYGKVEFVFS YGPEKIQGME HLENGPSVSV DYNTSDPLIR WDSYDNFSGH RDDGMEEVVG
   481  HTQGPLDGSL YAKVKKKDSL HGSTGAVNAT RPTLSATPNH VEHTLSVSSD SGNSTASTKT
   541  DKTDEPVPGA SSATAALSPQ EKRELDRLLS GFGLEREKQG AMYHTQHLRS RPAGGSAVPS
   601  SGRHVVPAQV HVNGGALASE RETDILDDEL PNQDGHSAGS MGTLSSLDGV TNTSEGGYPE
   661  ALSPLTNGLD KSYPMEPMVN GGGYPYESAS RAGPAHAGHT APMRPSYSAQ EGLAGYQREG
   721  PHPAWPQPVT TSHYAHDPSG MFRSQSFSEA EPQLPPAPVR GGSSREAVQR GLNSWQQQQQ
   781  QQQQPRPPPR QQERAHLESL VASRPSPQPL AETPIPSLPE FPRAASQQEI EQSIETLNML
   841  MLDLEPASAA APLHKSQSVP GAWPGASPLS SQPLSGSSRQ SHPLTQSRSG YIPSGHSLGT
   901  PEPAPRASLE SVPPGRSYSP YDYQPCLAGP NQDFHSKSPA SSSLPAFLPT THSPPGPQQP
   961  PASLPGLTAQ PLLSPKEATS DPSRTPEEEP LNLEGLVAHR VAGVQAREKQ PAEPPAPLRR
  1021  RAASDGQYEN QSPEATSPRS PGVRSPVQCV SPELALTIAL NPGGRPKEPH LHSYKEAFEE
  1081  MEGTSPSSPP PSGVRSPPGL AKTPLSALGL KPHNPADILL HPTGEPRSYV ESVARTAVAG
  1141  PRAQDSEPKS FSAPATQAYG HEIPLRNGTL GGSFVSPSPL STSSPILSAD STSVGSFPSG
  1201  ESSDQGPRTP TQPLLESGFR SGSLGQPSPS AQRNYQSSSP LPTVGSSYSS PDYSLQHFSS
  1261  SPESQARAQF SVAGVHTVPG SPQARHRTVG TNTPPSPGFG WRAINPSMAA PSSPSLSHHQ
  1321  MMGPPGTGFH GSTVSSPQSS AATTPGSPSL CRHPAGVYQV SGLHNKVATT PGSPSLGRHP
  1381  GAHQGNLASG LHSNAIASPG SPSLGRHLGG SGSVVPGSPC LDRHVAYGGY STPEDRRPTL
  1441  SRQSSASGYQ APSTPSFPVS PAYYPGLSSP ATSPSPDSAA FRQGSPTPAL PEKRRMSVGD
  1501  RAGSLPNYAT INGKVSSPVA SGMSSPSGGS TVSFSHTLPD FSKYSMPDNS PETRAKVKFV
  1561  QDTSKYWYKP EISREQAIAL LKDQEPGAFI IRDSHSFRGA YGLAMKVSSP PPTIMQQNKK
  1621  GDMTHELVRH FLIETGPRGV KLKGCPNEPN FGSLSALVYQ HSIIPLALPC KLVIPNRDPT
  1681  DESKDSSGPA NSTADLLKQG AACNVLFVNS VDMESLTGPQ AISKATSETL AADPTPAATI
  1741  VHFKVSAQGI TLTDNQRKLF FRRHYPLNTV TFCDLDPQER KWMKTEGGAP AKLFGFVARK
  1801  QGSTTDNACH LFAELDPNQP ASAIVNFVSK VMLNAGQKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.56

Highest tissue expression

538 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.36

gnomAD pLI

0.06

gnomAD missense Z

0.55

DepMap mean gene effect

0.06

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell-substrate junction assembly
• fibroblast migration

Molecular functions

• actin binding
• phosphoprotein phosphatase activity
• RNA binding
• zinc ion binding

Cellular components

• cell surface
• cytoskeleton
• focal adhesion

Protein domainsUniProt · Pfam · InterPro

• SH2 domain
• Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
• Protein-tyrosine phosphatase, catalytic
• PTB/PI domain
• PH-like domain superfamily
• Tensin/EPS8 phosphotyrosine-binding domain
• Tensin phosphatase, C2 domain
• Protein-tyrosine phosphatase-like
• Tensin-type phosphatase domain
• Tensin, phosphotyrosine-binding domain
• Tensin-like, SH2 domain
• C2 domain superfamily
• SH2 domain superfamily
• C1-like domain superfamily
• Tensin Phosphatase
• SH2 domain
• Phorbol esters/diacylglycerol binding domain (C1 domain)
• Phosphotyrosine-binding domain
• C2 domain of PTEN tumour-suppressor protein

KeywordsUniProt

• Actin-binding
• Cell junction
• Cytoplasm
• Cytoskeleton
• Glycoprotein
• Hydrolase
• Metal-binding
• Phosphoprotein
• Protein phosphatase
• SH2 domain
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of TNS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• STARD8