Seroatlas · Human Serome Atlas

PRKCZ

Protein kinase C zeta type

Also known as: KPCZ_HUMAN, PKC2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q05513
Gene
PRKCZ
Ensembl
ENSG00000067606
Chromosome
1
Canonical length
592 aa
Protein class
Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Basal body,Cytosol,Flagellar centriole,Mid piece,End piece

OverviewNCBI Gene

Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

592 residues, UniProt reviewed canonical sequence.

>Q05513|PRKCZ
     1  MPSRTGPKME GSGGRVRLKA HYGGDIFITS VDAATTFEEL CEEVRDMCRL HQQHPLTLKW
    61  VDSEGDPCTV SSQMELEEAF RLARQCRDEG LIIHVFPSTP EQPGLPCPGE DKSIYRRGAR
   121  RWRKLYRANG HLFQAKRFNR RAYCGQCSER IWGLARQGYR CINCKLLVHK RCHGLVPLTC
   181  RKHMDSVMPS QEPPVDDKNE DADLPSEETD GIAYISSSRK HDSIKDDSED LKPVIDGMDG
   241  IKISQGLGLQ DFDLIRVIGR GSYAKVLLVR LKKNDQIYAM KVVKKELVHD DEDIDWVQTE
   301  KHVFEQASSN PFLVGLHSCF QTTSRLFLVI EYVNGGDLMF HMQRQRKLPE EHARFYAAEI
   361  CIALNFLHER GIIYRDLKLD NVLLDADGHI KLTDYGMCKE GLGPGDTTST FCGTPNYIAP
   421  EILRGEEYGF SVDWWALGVL MFEMMAGRSP FDIITDNPDM NTEDYLFQVI LEKPIRIPRF
   481  LSVKASHVLK GFLNKDPKER LGCRPQTGFS DIKSHAFFRS IDWDLLEKKQ ALPPFQPQIT
   541  DDYGLDNFDT QFTSEPVQLT PDDEDAIKRI DQSEFEGFEY INPLLLSTEE SV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRKCZ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
137 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 137 nTPM
  • cerebral cortex: 81 nTPM
  • basal ganglia: 58 nTPM
  • hippocampal formation: 48 nTPM
  • amygdala: 47 nTPM
  • spinal cord: 44 nTPM

Single-cell type

  • syncytiotrophoblasts: 1,824 nCPM
  • late spermatids: 1,337 nCPM
  • alveolar cells type 1: 484 nCPM
  • transitional alveolar cells: 274 nCPM
  • early spermatids: 274 nCPM
  • alveolar cells type 2: 209 nCPM

Immune cell

  • eosinophil: 16 nTPM
  • MAIT T-cell: 2.5 nTPM
  • neutrophil: 1.1 nTPM
  • memory CD4 T-cell: 0.9 nTPM
  • NK-cell: 0.9 nTPM
  • T-reg: 0.9 nTPM

Brain region

  • cerebellum: 189 nTPM
  • cerebral cortex: 153 nTPM
  • basal ganglia: 119 nTPM
  • white matter: 118 nTPM
  • hippocampal formation: 117 nTPM
  • pons: 109 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.4
gnomAD pLI
0.54
gnomAD missense Z
2.8
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRKCZ in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRKCZ as an antibody target. Whether an autoantibody or antibody against PRKCZ could matter depends on whether native PRKCZ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRKCZ is annotated at the cell surface, where native PRKCZ is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PRKCZ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRKCZ. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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