Seroatlas · Human Serome Atlas

GTF2H2C

General transcription factor IIH subunit 2-like protein

Also known as: T2H2L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6P1K8
Gene
GTF2H2C
Ensembl
ENSG00000183474
Chromosome
5
Canonical length
395 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

Enables RNA polymerase II general transcription initiation factor activity. Involved in G protein-coupled receptor internalization and transcription initiation at RNA polymerase II promoter. Located in nuclear speck. Part of core TFIIH complex portion of holo TFIIH complex and transcription factor TFIID complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

395 residues, UniProt reviewed canonical sequence.

>Q6P1K8|GTF2H2C
     1  MDEEPERTKR WEGGYERTWE ILKEDESGSL KATIEDILFK AKRKRVFEHH GQVRLGMMRH
    61  LYVVVDGSRT MEDQDLKPNR LTCTLKLLEY FVEEYFDQNP ISQIGIIVTK SKRAEKLTEL
   121  SGNPRKHITS LKEAVDMTCH GEPSLYNSLS MAMQTLKHMP GHTSREVLII FSSLTTCDPS
   181  NIYDLIKTLK AAKIRVSVIG LSAEVRVCTV LARETGGTYH VILDESHYKE LLTHHLSPPP
   241  ASSSSECSLI RMGFPQHTIA SLSDQDAKPS FSMAHLDGNT EPGLTLGGYF CPQCRAKYCE
   301  LPVECKICGL TLVSAPHLAR SYHHLFPLDA FQEIPLEEYN GERFCYGCQG ELKDQHVYVC
   361  AVCQNVFCVD CDVFVHDSLH CCPGCIHKIP APSGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GTF2H2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
7.6 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 7.6 nTPM
  • ovary: 7.1 nTPM
  • endometrium: 6.9 nTPM
  • pancreas: 6.9 nTPM
  • cervix: 6.8 nTPM
  • lung: 6.2 nTPM

Single-cell type

  • renal collecting duct intercalated cells: 60 nCPM
  • loop of henle epithelial cells: 49 nCPM
  • distal convoluted tubule cells: 45 nCPM
  • renal collecting duct principal cells: 33 nCPM
  • renal connecting tubule cells: 31 nCPM
  • proximal tubule cells: 29 nCPM

Immune cell

  • basophil: 10 nTPM
  • neutrophil: 5.7 nTPM
  • naive CD8 T-cell: 2.5 nTPM
  • eosinophil: 2.1 nTPM
  • T-reg: 1.9 nTPM
  • naive B-cell: 1.8 nTPM

Brain region

  • white matter: 19 nTPM
  • cerebral cortex: 14 nTPM
  • cerebellum: 13 nTPM
  • pons: 12 nTPM
  • medulla oblongata: 12 nTPM
  • midbrain: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0.02
gnomAD missense Z
0.85

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GTF2H2C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GTF2H2C as an antibody target. Whether an autoantibody or antibody against GTF2H2C could matter depends on whether native GTF2H2C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GTF2H2C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GTF2H2C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GTF2H2C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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