KSR2

Protein identityUniProt · HPA

UniProt accession

Q6VAB6

Gene

KSR2

Ensembl

ENSG00000171435

Chromosome

12

Canonical length

950 aa

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins

OverviewNCBI Gene

Enables protein serine/threonine kinase activity. Predicted to be involved in Ras protein signal transduction; calcium-mediated signaling; and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within positive regulation of MAPK cascade. Predicted to be located in membrane. Predicted to be active in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

950 residues, UniProt reviewed canonical sequence.

>Q6VAB6|KSR2
     1  MDEENMTKSE EQQPLSLQKA LQQCELVQNM IDLSISNLEG LRTKCATSND LTQKEIRTLE
    61  SKLVKYFSRQ LSCKKKVALQ ERNAELDGFP QLRHWFRIVD VRKEVLEEIS PGQLSLEDLL
   121  EMTDEQVCET VEKYGANREE CARLNASLSC LRNVHMSGGN LSKQDWTIQW PTTETGKENN
   181  PVCPPEPTPW IRTHLSQSPR VPSKCVQHYC HTSPTPGAPV YTHVDRLTVD AYPGLCPPPP
   241  LESGHRSLPP SPRQRHAVRT PPRTPNIVTT VTPPGTPPMR KKNKLKPPGT PPPSSRKLIH
   301  LIPGFTALHR SKSHEFQLGH RVDEAHTPKA KKKSKPLNLK IHSSVGSCEN IPSQQRSPLL
   361  SERSLRSFFV GHAPFLPSTP PVHTEANFSA NTLSVPRWSP QIPRRDLGNS IKHRFSTKYW
   421  MSQTCTVCGK GMLFGLKCKN CKLKCHNKCT KEAPPCHLLI IHRGDPARLV RTESVPCDIN
   481  NPLRKPPRYS DLHISQTLPK TNKINKDHIP VPYQPDSSSN PSSTTSSTPS SPAPPLPPSA
   541  TPPSPLHPSP QCTRQQKNFN LPASHYYKYK QQFIFPDVVP VPETPTRAPQ VILHPVTSNP
   601  ILEGNPLLQI EVEPTSENEE VHDEAEESED DFEEMNLSLL SARSFPRKAS QTSIFLQEWD
   661  IPFEQLEIGE LIGKGRFGQV YHGRWHGEVA IRLIDIERDN EDQLKAFKRE VMAYRQTRHE
   721  NVVLFMGACM SPPHLAIITS LCKGRTLYSV VRDAKIVLDV NKTRQIAQEI VKGMGYLHAK
   781  GILHKDLKSK NVFYDNGKVV ITDFGLFSIS GVLQAGRRED KLRIQNGWLC HLAPEIIRQL
   841  SPDTEEDKLP FSKHSDVFAL GTIWYELHAR EWPFKTQPAE AIIWQMGTGM KPNLSQIGMG
   901  KEISDILLFC WAFEQEERPT FTKLMDMLEK LPKRNRRLSH PGHFWKSAEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KSR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.49

Highest tissue expression

7.4 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KSR2.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 431 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• KSR2-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.13

gnomAD pLI

1

gnomAD missense Z

3.34

DepMap mean gene effect

0

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• calcium-mediated signaling
• positive regulation of cold-induced thermogenesis
• positive regulation of MAPK cascade
• Ras protein signal transduction

Molecular functions

• ATP binding
• MAP-kinase scaffold activity
• mitogen-activated protein kinase kinase binding
• protein kinase activity
• protein serine kinase activity
• protein serine/threonine kinase activity
• zinc ion binding

Cellular components

• cytoplasm
• cytosol
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Serine-threonine/tyrosine-protein kinase, catalytic domain
• Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Sterile alpha motif/pointed domain superfamily
• C1-like domain superfamily
• Kinase suppressor RAS 1, N-terminal helical hairpin
• Kinase suppressor RAS 1, N-terminal helical hairpin superfamily
• Serine/threonine-protein kinase
• Protein tyrosine and serine/threonine kinase
• Kinase suppressor RAS 1 N-terminal helical hairpin
• Kinase suppressor of RAS, SAM-like domain
• SAM like domain present in kinase suppressor RAS 1

KeywordsUniProt

• ATP-binding
• Cytoplasm
• Kinase
• Membrane
• Metal-binding
• Nucleotide-binding
• Phosphoprotein
• Serine/threonine-protein kinase
• Transferase
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of KSR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BRAF
• MAP2K1
• MAP3K8
• MAPK
• RAF
• RAS
• RAF1
• HSP90AA1
• MAP2K2
• YWHAE
• YWHAG