CDC42BPA

Protein identityUniProt · HPA

UniProt accession

Q5VT25

Gene

CDC42BPA

Ensembl

ENSG00000143776

Chromosome

1

Canonical length

1732 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Plasma membrane,Cytosol

Quaternary structure

Homotetramer

OverviewNCBI Gene

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2018]

Canonical amino-acid sequenceUniProt

1732 residues, UniProt reviewed canonical sequence.

>Q5VT25|CDC42BPA
     1  MSGEVRLRQL EQFILDGPAQ TNGQCFSVET LLDILICLYD ECNNSPLRRE KNILEYLEWA
    61  KPFTSKVKQM RLHREDFEIL KVIGRGAFGE VAVVKLKNAD KVFAMKILNK WEMLKRAETA
   121  CFREERDVLV NGDNKWITTL HYAFQDDNNL YLVMDYYVGG DLLTLLSKFE DRLPEDMARF
   181  YLAEMVIAID SVHQLHYVHR DIKPDNILMD MNGHIRLADF GSCLKLMEDG TVQSSVAVGT
   241  PDYISPEILQ AMEDGKGRYG PECDWWSLGV CMYEMLYGET PFYAESLVET YGKIMNHKER
   301  FQFPAQVTDV SENAKDLIRR LICSREHRLG QNGIEDFKKH PFFSGIDWDN IRNCEAPYIP
   361  EVSSPTDTSN FDVDDDCLKN SETMPPPTHT AFSGHHLPFV GFTYTSSCVL SDRSCLRVTA
   421  GPTSLDLDVN VQRTLDNNLA TEAYERRIKR LEQEKLELSR KLQESTQTVQ ALQYSTVDGP
   481  LTASKDLEIK NLKEEIEKLR KQVTESSHLE QQLEEANAVR QELDDAFRQI KAYEKQIKTL
   541  QQEREDLNKE LVQASERLKN QSKELKDAHC QRKLAMQEFM EINERLTELH TQKQKLARHV
   601  RDKEEEVDLV MQKVESLRQE LRRTERAKKE LEVHTEALAA EASKDRKLRE QSEHYSKQLE
   661  NELEGLKQKQ ISYSPGVCSI EHQQEITKLK TDLEKKSIFY EEELSKREGI HANEIKNLKK
   721  ELHDSEGQQL ALNKEIMILK DKLEKTRRES QSEREEFESE FKQQYEREKV LLTEENKKLT
   781  SELDKLTTLY ENLSIHNQQL EEEVKDLADK KESVAHWEAQ ITEIIQWVSD EKDARGYLQA
   841  LASKMTEELE ALRNSSLGTR ATDMPWKMRR FAKLDMSARL ELQSALDAEI RAKQAIQEEL
   901  NKVKASNIIT ECKLKDSEKK NLELLSEIEQ LIKDTEELRS EKGIEHQDSQ HSFLAFLNTP
   961  TDALDQFERS PSCTPASKGR RTVDSTPLSV HTPTLRKKGC PGSTGFPPKR KTHQFFVKSF
  1021  TTPTKCHQCT SLMVGLIRQG CSCEVCGFSC HITCVNKAPT TCPVPPEQTK GPLGIDPQKG
  1081  IGTAYEGHVR IPKPAGVKKG WQRALAIVCD FKLFLYDIAE GKASQPSVVI SQVIDMRDEE
  1141  FSVSSVLASD VIHASRKDIP CIFRVTASQL SASNNKCSIL MLADTENEKN KWVGVLSELH
  1201  KILKKNKFRD RSVYVPKEAY DSTLPLIKTT QAAAIIDHER IALGNEEGLF VVHVTKDEII
  1261  RVGDNKKIHQ IELIPNDQLV AVISGRNRHV RLFPMSALDG RETDFYKLSE TKGCQTVTSG
  1321  KVRHGALTCL CVAMKRQVLC YELFQSKTRH RKFKEIQVPY NVQWMAIFSE QLCVGFQSGF
  1381  LRYPLNGEGN PYSMLHSNDH TLSFIAHQPM DAICAVEISS KEYLLCFNSI GIYTDCQGRR
  1441  SRQQELMWPA NPSSCCYNAP YLSVYSENAV DIFDVNSMEW IQTLPLKKVR PLNNEGSLNL
  1501  LGLETIRLIY FKNKMAEGDE LVVPETSDNS RKQMVRNINN KRRYSFRVPE EERMQQRREM
  1561  LRDPEMRNKL ISNPTNFNHI AHMGPGDGIQ ILKDLPMNPR PQESRTVFSG SVSIPSITKS
  1621  RPEPGRSMSA SSGLSARSSA QNGSALKREF SGGSYSAKRQ PMPSPSEGSL SSGGMDQGSD
  1681  APARDFDGED SDSPRHSTAS NSSNLSSPPS PASPRKTKSL SLESTDRGSW DP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC42BPA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

28 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.28

gnomAD pLI

0.99

gnomAD missense Z

2.39

DepMap mean gene effect

-0.06

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• actin cytoskeleton organization
• actomyosin structure organization
• cell migration
• protein phosphorylation

Molecular functions

• ATP binding
• identical protein binding
• magnesium ion binding
• protein serine kinase activity
• protein serine/threonine kinase activity
• zinc ion binding

Cellular components

• actomyosin
• cell leading edge
• cell-cell junction
• cytoplasm
• cytoskeleton
• cytosol
• extracellular exosome
• lamellipodium

Protein domainsUniProt · Pfam · InterPro

• CRIB domain
• Protein kinase domain
• AGC-kinase, C-terminal
• Citron homology (CNH) domain
• Pleckstrin homology domain
• Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• PH-like domain superfamily
• Myotonic dystrophy protein kinase, coiled coil
• Protein kinase, ATP binding site
• Protein kinase, C-terminal
• KELK-motif containing domain
• C1-like domain superfamily
• Rho-associated Serine/Threonine Kinase
• MRCK/ROCK kinase, PH domain
• Protein kinase domain
• Phorbol esters/diacylglycerol binding domain (C1 domain)
• Protein kinase C terminal domain
• CNH domain
• DMPK coiled coil domain like
• KELK-motif containing domain of MRCK Ser/Thr protein kinase
• MRCK kinase PH domain
• Serine/threonine-protein kinase MRCK alpha, catalytic domain

KeywordsUniProt

• ATP-binding
• Cell projection
• Coiled coil
• Cytoplasm
• Kinase
• Magnesium
• Metal-binding
• Nucleotide-binding
• Phosphoprotein
• Serine/threonine-protein kinase
• Transferase
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of CDC42BPA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• LURAP1
• CDC42
• CDC42BPB
• YWHAE
• YWHAZ