Seroatlas · Human Serome Atlas

RASSF5

Ras association domain-containing protein 5

Also known as: Maxp1, NORE1, RAPL, RASF5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WWW0
Gene: RASSF5
Ensembl: ENSG00000266094
Chromosome: 1
Canonical length: 418 aa
Protein class: Predicted intracellular proteins, RAS pathway related proteins

OverviewNCBI Gene

This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

418 residues, UniProt reviewed canonical sequence.

>Q8WWW0|RASSF5
     1  MAMASPAIGQ RPYPLLLDPE PPRYLQSLSG PELPPPPPDR SSRLCVPAPL STAPGAREGR
    61  SARRAARGNL EPPPRASRPA RPLRPGLQQR LRRRPGAPRP RDVRSIFEQP QDPRVPAERG
   121  EGHCFAELVL PGGPGWCDLC GREVLRQALR CTNCKFTCHP ECRSLIQLDC SQQEGLSRDR
   181  PSPESTLTVT FSQNVCKPVE ETQRPPTLQE IKQKIDSYNT REKNCLGMKL SEDGTYTGFI
   241  KVHLKLRRPV TVPAGIRPQS IYDAIKEVNL AATTDKRTSF YLPLDAIKQL HISSTTTVSE
   301  VIQGLLKKFM VVDNPQKFAL FKRIHKDGQV LFQKLSIADR PLYLRLLAGP DTEVLSFVLK
   361  ENETGEVEWD AFSIPELQNF LTILEKEEQD KIQQVQKKYD KFRQKLEEAL RESQGKPG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RASSF5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 103 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 103 nTPM
thymus: 78 nTPM
lymph node: 59 nTPM
tonsil: 56 nTPM
spleen: 53 nTPM
appendix: 45 nTPM

Single-cell type

neutrophils: 428 nCPM
esophageal apical cells: 200 nCPM
urothelial cells: 177 nCPM
mast cells: 175 nCPM
cdc: 144 nCPM
monocytes: 143 nCPM

Immune cell

eosinophil: 269 nTPM
basophil: 212 nTPM
neutrophil: 158 nTPM
total PBMC: 155 nTPM
NK-cell: 132 nTPM
memory CD8 T-cell: 117 nTPM

Brain region

thalamus: 19 nTPM
white matter: 17 nTPM
midbrain: 16 nTPM
pons: 15 nTPM
cerebral cortex: 15 nTPM
basal ganglia: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0.04
gnomAD missense Z: 1.11
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ras-associating domain
Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
SARAH domain
Ubiquitin-like domain superfamily
Ras association domain-containing protein 1-6
C1-like domain superfamily
Phorbol esters/diacylglycerol binding domain (C1 domain)
Ras association (RalGDS/AF-6) domain
Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
Ras association domain-containing protein 5, RA domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RASSF5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RASSF5 as an antibody target. Whether an autoantibody or antibody against RASSF5 could matter depends on whether native RASSF5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RASSF5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RASSF5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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