DGKQ

Protein identityUniProt · HPA

UniProt accession

P52824

Gene

DGKQ

Ensembl

ENSG00000145214

Chromosome

4

Canonical length

942 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoli

OverviewNCBI Gene

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

942 residues, UniProt reviewed canonical sequence.

>P52824|DGKQ
     1  MAAAAEPGAR AWLGGGSPRP GSPACSPVLG SGGRARPGPG PGPGPERAGV RAPGPAAAPG
    61  HSFRKVTLTK PTFCHLCSDF IWGLAGFLCD VCNFMSHEKC LKHVRIPCTS VAPSLVRVPV
   121  AHCFGPRGLH KRKFCAVCRK VLEAPALHCE VCELHLHPDC VPFACSDCRQ CHQDGHQDHD
   181  THHHHWREGN LPSGARCEVC RKTCGSSDVL AGVRCEWCGV QAHSLCSAAL APECGFGRLR
   241  SLVLPPACVR LLPGGFSKTQ SFRIVEAAEP GEGGDGADGS AAVGPGRETQ ATPESGKQTL
   301  KIFDGDDAVR RSQFRLVTVS RLAGAEEVLE AALRAHHIPE DPGHLELCRL PPSSQACDAW
   361  AGGKAGSAVI SEEGRSPGSG EATPEAWVIR ALPRAQEVLK IYPGWLKVGV AYVSVRVTPK
   421  STARSVVLEV LPLLGRQAES PESFQLVEVA MGCRHVQRTM LMDEQPLLDR LQDIRQMSVR
   481  QVSQTRFYVA ESRDVAPHVS LFVGGLPPGL SPEEYSSLLH EAGATKATVV SVSHIYSSQG
   541  AVVLDVACFA EAERLYMLLK DMAVRGRLLT ALVLPDLLHA KLPPDSCPLL VFVNPKSGGL
   601  KGRDLLCSFR KLLNPHQVFD LTNGGPLPGL HLFSQVPCFR VLVCGGDGTV GWVLGALEET
   661  RYRLACPEPS VAILPLGTGN DLGRVLRWGA GYSGEDPFSV LLSVDEADAV LMDRWTILLD
   721  AHEAGSAEND TADAEPPKIV QMSNYCGIGI DAELSLDFHQ AREEEPGKFT SRLHNKGVYV
   781  RVGLQKISHS RSLHKQIRLQ VERQEVELPS IEGLIFINIP SWGSGADLWG SDSDTRFEKP
   841  RMDDGLLEVV GVTGVVHMGQ VQGGLRSGIR IAQGSYFRVT LLKATPVQVD GEPWVQAPGH
   901  MIISAAGPKV HMLRKAKQKP RRAGTTRDAR ADAAPAPESD PR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DGKQ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

26 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.7

gnomAD pLI

0

gnomAD missense Z

0.1

DepMap mean gene effect

0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-activating G protein-coupled receptor signaling pathway
• cellular response to bile acid
• diacylglycerol metabolic process
• epidermal growth factor receptor signaling pathway
• G protein-coupled receptor signaling pathway
• glycerolipid metabolic process
• intracellular signal transduction
• lipid phosphorylation
• negative regulation of gene expression
• phosphatidic acid biosynthetic process
• phospholipase C-activating G protein-coupled receptor signaling pathway
• platelet activation
• positive regulation of gene expression
• positive regulation of protein kinase C signaling
• regulation of cholesterol metabolic process
• regulation of cortisol biosynthetic process
• regulation of gluconeogenesis
• regulation of progesterone biosynthetic process
• regulation of synaptic vesicle endocytosis
• regulation of TORC1 signaling
• regulation of transcription by RNA polymerase II
• response to cAMP
• thrombin-activated receptor signaling pathway

Molecular functions

• alkylglycerol kinase activity
• ATP binding
• ATP-dependent diacylglycerol kinase activity
• diacylglycerol-dependent serine/threonine kinase activity
• DNA-binding transcription factor binding
• kinase binding
• phospholipase binding
• receptor tyrosine kinase binding
• transmembrane receptor protein tyrosine kinase activator activity
• zinc ion binding

Cellular components

• cytoplasm
• cytoskeleton
• cytosol
• endosome
• glutamatergic synapse
• membrane
• nuclear matrix
• nuclear speck
• nucleolus
• nucleus
• plasma membrane
• postsynapse
• presynapse
• vesicle membrane

Protein domainsUniProt · Pfam · InterPro

• Ras-associating domain
• Diacylglycerol kinase, accessory domain
• Diacylglycerol kinase, catalytic domain
• Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
• NAD kinase/diacylglycerol kinase-like domain superfamily
• Inorganic polyphosphate/ATP-NAD kinase, N-terminal
• Ubiquitin-like domain superfamily
• Diacylglycerol kinase
• C1-like domain superfamily
• Phorbol esters/diacylglycerol binding domain (C1 domain)
• Diacylglycerol kinase accessory domain
• Diacylglycerol kinase catalytic domain
• Ras association (RalGDS/AF-6) domain
• Diacylglycerol kinase theta, RNA-binding domain
• Diacylglycerol kinase theta, RNA-binding domain-like

KeywordsUniProt

• ATP-binding
• Cell membrane
• Cytoplasm
• Cytoskeleton
• Kinase
• Lipid metabolism
• Membrane
• Metal-binding
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Repeat
• Synapse
• Transferase
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of DGKQ in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NR5A1
• PLCB1
• PRKCE
• PRKCH
• RHOA