PRKD2

Protein identityUniProt · HPA

UniProt accession

Q9BZL6

Gene

PRKD2

Ensembl

ENSG00000105287

Chromosome

19

Canonical length

878 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

878 residues, UniProt reviewed canonical sequence.

>Q9BZL6|PRKD2
     1  MATAPSYPAG LPGSPGPGSP PPPGGLELQS PPPLLPQIPA PGSGVSFHIQ IGLTREFVLL
    61  PAASELAHVK QLACSIVDQK FPECGFYGLY DKILLFKHDP TSANLLQLVR SSGDIQEGDL
   121  VEVVLSASAT FEDFQIRPHA LTVHSYRAPA FCDHCGEMLF GLVRQGLKCD GCGLNYHKRC
   181  AFSIPNNCSG ARKRRLSSTS LASGHSVRLG TSESLPCTAE ELSRSTTELL PRRPPSSSSS
   241  SSASSYTGRP IELDKMLLSK VKVPHTFLIH SYTRPTVCQA CKKLLKGLFR QGLQCKDCKF
   301  NCHKRCATRV PNDCLGEALI NGDVPMEEAT DFSEADKSAL MDESEDSGVI PGSHSENALH
   361  ASEEEEGEGG KAQSSLGYIP LMRVVQSVRH TTRKSSTTLR EGWVVHYSNK DTLRKRHYWR
   421  LDCKCITLFQ NNTTNRYYKE IPLSEILTVE SAQNFSLVPP GTNPHCFEIV TANATYFVGE
   481  MPGGTPGGPS GQGAEAARGW ETAIRQALMP VILQDAPSAP GHAPHRQASL SISVSNSQIQ
   541  ENVDIATVYQ IFPDEVLGSG QFGVVYGGKH RKTGRDVAVK VIDKLRFPTK QESQLRNEVA
   601  ILQSLRHPGI VNLECMFETP EKVFVVMEKL HGDMLEMILS SEKGRLPERL TKFLITQILV
   661  ALRHLHFKNI VHCDLKPENV LLASADPFPQ VKLCDFGFAR IIGEKSFRRS VVGTPAYLAP
   721  EVLLNQGYNR SLDMWSVGVI MYVSLSGTFP FNEDEDINDQ IQNAAFMYPA SPWSHISAGA
   781  IDLINNLLQV KMRKRYSVDK SLSHPWLQEY QTWLDLRELE GKMGERYITH ESDDARWEQF
   841  AAEHPLPGSG LPTDRDLGGA CPPQDHDMQG LAERISVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRKD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

47 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.19

gnomAD pLI

1

gnomAD missense Z

3.68

DepMap mean gene effect

-0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adaptive immune response
• angiogenesis
• cell adhesion
• cellular response to vascular endothelial growth factor stimulus
• endothelial tube morphogenesis
• intracellular signal transduction
• phospholipase C-activating G protein-coupled receptor signaling pathway
• positive regulation of angiogenesis
• positive regulation of blood vessel endothelial cell migration
• positive regulation of cell adhesion
• positive regulation of DNA biosynthetic process
• positive regulation of DNA-binding transcription factor activity
• positive regulation of endothelial cell chemotaxis
• positive regulation of endothelial cell migration
• positive regulation of endothelial cell proliferation
• positive regulation of ERK1 and ERK2 cascade
• positive regulation of fibroblast growth factor receptor signaling pathway
• positive regulation of interleukin-2 production
• positive regulation of interleukin-8 production
• positive regulation of NF-kappaB transcription factor activity
• positive regulation of T cell receptor signaling pathway
• positive regulation of transcription by RNA polymerase II
• positive regulation of vascular endothelial growth factor receptor signaling pathway
• protein phosphorylation
• regulation of T cell apoptotic process
• sphingolipid biosynthetic process
• T cell receptor signaling pathway
• vascular endothelial growth factor receptor signaling pathway

Molecular functions

• ATP binding
• diacylglycerol-dependent serine/threonine kinase activity
• protein kinase activity
• protein kinase C binding
• protein serine kinase activity
• protein serine/threonine kinase activity
• zinc ion binding

Cellular components

• cytoplasm
• cytosol
• Golgi apparatus
• nucleoplasm
• nucleus
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Pleckstrin homology domain
• Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• PH-like domain superfamily
• Protein kinase C mu-related
• Protein kinase, ATP binding site
• Diacylglycerol/phorbol-ester binding
• C1-like domain superfamily
• Serine/threonine-protein kinase D1-3-like, ubiquitin-like domain
• Protein kinase domain
• Phorbol esters/diacylglycerol binding domain (C1 domain)
• PH domain
• Serine/threonine-protein kinase D1-like, ubiquitin-like domain

KeywordsUniProt

• Adaptive immunity
• Angiogenesis
• ATP-binding
• Cell adhesion
• Cell membrane
• Cytoplasm
• Golgi apparatus
• Immunity
• Kinase
• Magnesium
• Membrane
• Metal-binding
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Repeat
• Serine/threonine-protein kinase
• Transferase
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of PRKD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PRKCD
• CIB1
• GLRX3