Seroatlas · Human Serome Atlas

PRKCI

Protein kinase C iota type

Also known as: DXS1179E, KPCI_HUMAN, PKCI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P41743
Gene
PRKCI
Ensembl
ENSG00000163558
Chromosome
3
Canonical length
596 aa
Protein class
Cancer-related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins
Subcellular location
Microtubules,Cytokinetic bridge,Primary cilium,Cytosol

OverviewNCBI Gene

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

596 residues, UniProt reviewed canonical sequence.

>P41743|PRKCI
     1  MPTQRDSSTM SHTVAGGGSG DHSHQVRVKA YYRGDIMITH FEPSISFEGL CNEVRDMCSF
    61  DNEQLFTMKW IDEEGDPCTV SSQLELEEAF RLYELNKDSE LLIHVFPCVP ERPGMPCPGE
   121  DKSIYRRGAR RWRKLYCANG HTFQAKRFNR RAHCAICTDR IWGLGRQGYK CINCKLLVHK
   181  KCHKLVTIEC GRHSLPQEPV MPMDQSSMHS DHAQTVIPYN PSSHESLDQV GEEKEAMNTR
   241  ESGKASSSLG LQDFDLLRVI GRGSYAKVLL VRLKKTDRIY AMKVVKKELV NDDEDIDWVQ
   301  TEKHVFEQAS NHPFLVGLHS CFQTESRLFF VIEYVNGGDL MFHMQRQRKL PEEHARFYSA
   361  EISLALNYLH ERGIIYRDLK LDNVLLDSEG HIKLTDYGMC KEGLRPGDTT STFCGTPNYI
   421  APEILRGEDY GFSVDWWALG VLMFEMMAGR SPFDIVGSSD NPDQNTEDYL FQVILEKQIR
   481  IPRSLSVKAA SVLKSFLNKD PKERLGCHPQ TGFADIQGHP FFRNVDWDMM EQKQVVPPFK
   541  PNISGEFGLD NFDSQFTNEP VQLTPDDDDI VRKIDQSEFE GFEYINPLLM SAEECV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRKCI can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 33 nTPM
  • thyroid gland: 23 nTPM
  • salivary gland: 17 nTPM
  • prostate: 16 nTPM
  • lung: 16 nTPM
  • urinary bladder: 15 nTPM

Single-cell type

  • podocytes: 383 nCPM
  • prostatic club cells: 361 nCPM
  • alveolar cells type 2: 315 nCPM
  • salivary ionocytes: 277 nCPM
  • transitional alveolar cells: 268 nCPM
  • sertoli cells: 268 nCPM

Immune cell

  • NK-cell: 2.6 nTPM
  • memory CD8 T-cell: 2 nTPM
  • MAIT T-cell: 1.7 nTPM
  • naive CD4 T-cell: 1.6 nTPM
  • memory CD4 T-cell: 1.5 nTPM
  • naive B-cell: 1.2 nTPM

Brain region

  • cerebral cortex: 19 nTPM
  • hippocampal formation: 18 nTPM
  • basal ganglia: 17 nTPM
  • cerebellum: 16 nTPM
  • hypothalamus: 15 nTPM
  • white matter: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.07
gnomAD missense Z
2.79
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRKCI in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRKCI as an antibody target. Whether an autoantibody or antibody against PRKCI could matter depends on whether native PRKCI is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRKCI is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRKCI as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRKCI. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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