Seroatlas · Human Serome Atlas

SRP68

Signal recognition particle subunit SRP68

Also known as: SRP68_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UHB9
Gene
SRP68
Ensembl
ENSG00000167881
Chromosome
17
Canonical length
627 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

627 residues, UniProt reviewed canonical sequence.

>Q9UHB9|SRP68
     1  MAAEKQVPGG GGGGGSGGGG GSGGGGSGGG RGAGGEENKE NERPSAGSKA NKEFGDSLSL
    61  EILQIIKESQ QQHGLRHGDF QRYRGYCSRR QRRLRKTLNF KMGNRHKFTG KKVTEELLTD
   121  NRYLLLVLMD AERAWSYAMQ LKQEANTEPR KRFHLLSRLR KAVKHAEELE RLCESNRVDA
   181  KTKLEAQAYT AYLSGMLRFE HQEWKAAIEA FNKCKTIYEK LASAFTEEQA VLYNQRVEEI
   241  SPNIRYCAYN IGDQSAINEL MQMRLRSGGT EGLLAEKLEA LITQTRAKQA ATMSEVEWRG
   301  RTVPVKIDKV RIFLLGLADN EAAIVQAESE ETKERLFESM LSECRDAIQV VREELKPDQK
   361  QRDYILEGEP GKVSNLQYLH SYLTYIKLST AIKRNENMAK GLQRALLQQQ PEDDSKRSPR
   421  PQDLIRLYDI ILQNLVELLQ LPGLEEDKAF QKEIGLKTLV FKAYRCFFIA QSYVLVKKWS
   481  EALVLYDRVL KYANEVNSDA GAFKNSLKDL PDVQELITQV RSEKCSLQAA AILDANDAHQ
   541  TETSSSQVKD NKPLVERFET FCLDPSLVTK QANLVHFPPG FQPIPCKPLF FDLALNHVAF
   601  PPLEDKLEQK TKSGLTGYIK GIFGFRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRP68 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
83 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 83 nTPM
  • pancreas: 51 nTPM
  • tongue: 44 nTPM
  • blood vessel: 39 nTPM
  • esophagus: 36 nTPM
  • parathyroid gland: 36 nTPM

Single-cell type

  • esophageal apical cells: 301 nCPM
  • syncytiotrophoblasts: 209 nCPM
  • esophageal suprabasal cells: 122 nCPM
  • cytotrophoblasts: 107 nCPM
  • migrating cytotrophoblasts: 99 nCPM
  • esophageal basal cells: 79 nCPM

Immune cell

  • NK-cell: 46 nTPM
  • naive CD4 T-cell: 39 nTPM
  • memory CD8 T-cell: 38 nTPM
  • eosinophil: 37 nTPM
  • memory CD4 T-cell: 35 nTPM
  • T-reg: 35 nTPM

Brain region

  • medulla oblongata: 645 nTPM
  • cerebral cortex: 438 nTPM
  • pons: 81 nTPM
  • hippocampal formation: 47 nTPM
  • spinal cord: 39 nTPM
  • hypothalamus: 33 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SRP68.

Disease | AllUniProt

Conditions SRP68 is implicated in, by any mechanism.

  • Neutropenia, severe congenital, 10, autosomal recessive (SCN10) MIM:620534

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 104 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Neutropenia, severe congenital, 10, autosomal recessive

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.45
gnomAD pLI
0.05
gnomAD missense Z
2.03
DepMap mean gene effect
-0.98
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Signal recognition particle subunit SRP68
  • Signal recognition particle subunit SRP68, RNA-binding domain
  • SRP68, N-terminal domain superfamily
  • RNA-binding signal recognition particle 68

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRP68 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRP68 as an antibody target. Whether an autoantibody or antibody against SRP68 could matter depends on whether native SRP68 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRP68 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRP68 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SRP68. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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