Seroatlas · Human Serome Atlas

RPL8

Large ribosomal subunit protein uL2

Also known as: L8, RL8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62917
Gene
RPL8
Ensembl
ENSG00000161016
Chromosome
8
Canonical length
257 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nucleoli,Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

257 residues, UniProt reviewed canonical sequence.

>P62917|RPL8
     1  MGRVIRGQRK GAGSVFRAHV KHRKGAARLR AVDFAERHGY IKGIVKDIIH DPGRGAPLAK
    61  VVFRDPYRFK KRTELFIAAE GIHTGQFVYC GKKAQLNIGN VLPVGTMPEG TIVCCLEEKP
   121  GDRGKLARAS GNYATVISHN PETKKTRVKL PSGSKKVISS ANRAVVGVVA GGGRIDKPIL
   181  KAGRAYHKYK AKRNCWPRVR GVAMNPVEHP FGGGNHQHIG KPSTIRRDAP AGRKVGLIAA
   241  RRTGRLRGTK TVQEKEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
2,090 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 2,090 nTPM
  • pancreas: 1,930 nTPM
  • skin: 1,698 nTPM
  • skeletal muscle: 1,548 nTPM
  • esophagus: 1,328 nTPM
  • salivary gland: 1,245 nTPM

Single-cell type

  • esophageal suprabasal cells: 10,648 nCPM
  • esophageal basal cells: 9,307 nCPM
  • esophageal apical cells: 8,676 nCPM
  • extravillous trophoblasts: 8,303 nCPM
  • decidual stromal cells: 7,962 nCPM
  • gastric progenitor cells: 6,775 nCPM

Immune cell

  • total PBMC: 5,472 nTPM
  • naive B-cell: 3,005 nTPM
  • memory B-cell: 2,983 nTPM
  • naive CD4 T-cell: 2,189 nTPM
  • T-reg: 2,077 nTPM
  • myeloid DC: 2,055 nTPM

Brain region

  • spinal cord: 294 nTPM
  • thalamus: 286 nTPM
  • white matter: 279 nTPM
  • medulla oblongata: 277 nTPM
  • pons: 243 nTPM
  • choroid plexus: 240 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.96
gnomAD missense Z
1.75
DepMap mean gene effect
-2.41
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL8 as an antibody target. Whether an autoantibody or antibody against RPL8 could matter depends on whether native RPL8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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