SRP14
Signal recognition particle 14 kDa protein
Also known as: ALURBP, MGC14326, SRP14_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P37108
- Gene
- SRP14
- Ensembl
- ENSG00000140319
- Chromosome
- 15
- Canonical length
- 136 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins, Transporters
- Subcellular location
- Nucleoplasm,Nucleoli
OverviewNCBI Gene
Enables RNA binding activity. Involved in protein targeting to ER. Located in nucleus. Part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
136 residues, UniProt reviewed canonical sequence.
>P37108|SRP14
1 MVLLESEQFL TELTRLFQKC RTSGSVYITL KKYDGRTKPI PKKGTVEGFE PADNKCLLRA
61 TDGKKKISTV VSSKEVNKFQ MAYSNLLRAN MDGLKKRDKK NKTKKTKAAA AAAAAAPAAA
121 ATAPTTAATT AATAAQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SRP14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.49
- Highest tissue expression
- 426 nTPM
Expression across tissuesHPA
Tissue
- kidney: 426 nTPM
- midbrain: 423 nTPM
- basal ganglia: 417 nTPM
- choroid plexus: 407 nTPM
- cerebral cortex: 399 nTPM
- amygdala: 394 nTPM
Single-cell type
- esophageal apical cells: 2,562 nCPM
- endometrial luminal cells: 2,198 nCPM
- esophageal suprabasal cells: 1,785 nCPM
- parietal cells: 1,757 nCPM
- extravillous trophoblasts: 1,325 nCPM
- hofbauer cells: 1,213 nCPM
Immune cell
- total PBMC: 1,266 nTPM
- plasmacytoid DC: 1,152 nTPM
- eosinophil: 879 nTPM
- T-reg: 758 nTPM
- basophil: 734 nTPM
- memory B-cell: 604 nTPM
Brain region
- midbrain: 318 nTPM
- cerebral cortex: 299 nTPM
- medulla oblongata: 222 nTPM
- white matter: 207 nTPM
- hypothalamus: 198 nTPM
- pons: 193 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.44
- gnomAD pLI
- 0.87
- gnomAD missense Z
- 0.84
- DepMap mean gene effect
- -0.87
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cotranslational protein targeting to membrane
- protein targeting to ER
- SRP-dependent cotranslational protein targeting to membrane
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Signal recognition particle, SRP9/SRP14 subunit
- Signal recognition particle, SRP14 subunit
- Signal recognition particle 14kD protein
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SRP14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SRP14 as an antibody target. Whether an autoantibody or antibody against SRP14 could matter depends on whether native SRP14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SRP14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SRP14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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