Seroatlas · Human Serome Atlas

FTSJ3

pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

Also known as: SPB1, SPB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IY81
Gene: FTSJ3
Ensembl: ENSG00000108592
Chromosome: 17
Canonical length: 847 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Nucleoli rim,Mitotic chromosome

OverviewNCBI Gene

Although the function of this gene is not known, the existence of this gene is supported by mRNA and EST data. A possible function of the encoded protein can be inferred from amino acid sequence similarity to the E.coli FtsJ protein and to a mouse protein possibly involved in embryogenesis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

847 residues, UniProt reviewed canonical sequence.

>Q8IY81|FTSJ3
     1  MGKKGKVGKS RRDKFYHLAK ETGYRSRSAF KLIQLNRRFQ FLQKARALLD LCAAPGGWLQ
    61  VAAKFMPVSS LIVGVDLVPI KPLPNVVTLQ QDITTERCRQ ALRKELKTWK VDVVLNDGAP
   121  NVGASWVHDA YSQAHLTLMA LRLACDFLAR GGSFITKVFR SRDYQPLLWI FQQLFRRVQA
   181  TKPQASRHES AEIFVVCQGF LAPDKVDSKF FDPKFAFKEV EVQAKTVTEL VTKKKPKAEG
   241  YAEGDLTLYH RTSVTDFLRA ANPVDFLSKA SEIMVDDEEL AQHPATTEDI RVCCQDIRVL
   301  GRKELRSLLN WRTKLRRYVA KKLKEQAKAL DISLSSGEED EGDEEDSTAG TTKQPSKEEE
   361  EEEEEEQLNQ TLAEMKAQEV AELKRKKKKL LREQRKQRER VELKMDLPGV SIADEGETGM
   421  FSLSTIRGHQ LLEEVTQGDM SAADTFLSDL PRDDIYVSDV EDDGDDTSLD SDLDPEELAG
   481  VRGHQGLRDQ KRMRLTEVQD DKEEEEEENP LLVPLEEKAV LQEEQANLWF SKGSFAGIED
   541  DADEALEISQ AQLLFENRRK GRQQQQKQQL PQTPPSCLKT EIMSPLYQDE APKGTEASSG
   601  TEAATGLEGE EKDGISDSDS STSSEEEESW EPLRGKKRSR GPKSDDDGFE IVPIEDPAKH
   661  RILDPEGLAL GAVIASSKKA KRDLIDNSFN RYTFNEDEGE LPEWFVQEEK QHRIRQLPVG
   721  KKEVEHYRKR WREINARPIK KVAEAKARKK RRMLKRLEQT RKKAEAVVNT VDISEREKVA
   781  QLRSLYKKAG LGKEKRHVTY VVAKKGVGRK VRRPAGVRGH FKVVDSRMKK DQRAQQRKEQ
   841  KKKHKRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FTSJ3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 27 nTPM
ovary: 24 nTPM
skin: 23 nTPM
tonsil: 22 nTPM
kidney: 22 nTPM
smooth muscle: 21 nTPM

Single-cell type

epicardial cells: 59 nCPM
cardiomyocytes: 44 nCPM
erythrocyte progenitors: 42 nCPM
thymic myoid cells: 37 nCPM
megakaryocyte-erythroid progenitors: 30 nCPM
prostatic glandular cells: 30 nCPM

Immune cell

T-reg: 15 nTPM
MAIT T-cell: 15 nTPM
memory CD8 T-cell: 15 nTPM
NK-cell: 14 nTPM
myeloid DC: 14 nTPM
intermediate monocyte: 13 nTPM

Brain region

medulla oblongata: 12 nTPM
white matter: 12 nTPM
spinal cord: 12 nTPM
thalamus: 12 nTPM
basal ganglia: 12 nTPM
cerebellum: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.04
gnomAD missense Z: -0.42
DepMap mean gene effect: -1.14
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ribosomal RNA methyltransferase, FtsJ domain
Ribosomal RNA large subunit methyltransferase E
S-adenosyl-L-methionine-dependent methyltransferase superfamily
Ribosomal RNA large subunit methyltransferase RlmE
FtsJ-like methyltransferase
Ribosomal RNA methyltransferase, SPB1-like, C-terminal
Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381
AdoMet-dependent rRNA methyltransferase SPB1-like
Spb1 C-terminal domain
Ribosomal RNA methyltransferase Spb1, DUF3381

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FTSJ3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FTSJ3 as an antibody target. Whether an autoantibody or antibody against FTSJ3 could matter depends on whether native FTSJ3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FTSJ3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FTSJ3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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