SRP9
Signal recognition particle 9 kDa protein
Also known as: SRP09_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P49458
- Gene
- SRP9
- Ensembl
- ENSG00000143742
- Chromosome
- 1
- Canonical length
- 86 aa
- Protein class
- Predicted intracellular proteins, Transporters
OverviewNCBI Gene
Predicted to enable RNA binding activity and signal recognition particle binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane. Predicted to be located in cytosol. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
86 residues, UniProt reviewed canonical sequence.
>P49458|SRP9
1 MPQYQTWEEF SRAAEKLYLA DPMKARVVLK YRHSDGNLCV KVTDDLVCLV YKTDQAQDVK
61 KIEKFHSQLM RLMVAKEARN VTMETELocalizationUniProt · AlphaFold · HPA
Whether an antibody against SRP9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.39
- Highest tissue expression
- 327 nTPM
Expression across tissuesHPA
Tissue
- liver: 327 nTPM
- thymus: 252 nTPM
- kidney: 249 nTPM
- tongue: 248 nTPM
- adrenal gland: 240 nTPM
- skeletal muscle: 239 nTPM
Single-cell type
- esophageal apical cells: 683 nCPM
- parietal cells: 606 nCPM
- megakaryocytes: 464 nCPM
- gastric progenitor cells: 429 nCPM
- esophageal suprabasal cells: 349 nCPM
- müller glia: 317 nCPM
Immune cell
- total PBMC: 638 nTPM
- T-reg: 459 nTPM
- naive CD4 T-cell: 397 nTPM
- eosinophil: 379 nTPM
- NK-cell: 372 nTPM
- myeloid DC: 355 nTPM
Brain region
- hypothalamus: 228 nTPM
- white matter: 202 nTPM
- spinal cord: 197 nTPM
- medulla oblongata: 187 nTPM
- thalamus: 185 nTPM
- cerebellum: 179 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.9
- gnomAD pLI
- 0.42
- gnomAD missense Z
- 1.13
- DepMap mean gene effect
- -1.11
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- SRP-dependent cotranslational protein targeting to membrane
- negative regulation of translational elongation
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Signal recognition particle, SRP9/SRP14 subunit
- Signal recognition particle SRP9
- SRP9 domain
- Signal recognition particle SRP9-like
- Signal recognition particle 9 kDa protein (SRP9)
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SRP9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SRP9 as an antibody target. Whether an autoantibody or antibody against SRP9 could matter depends on whether native SRP9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SRP9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SRP9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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