Seroatlas · Human Serome Atlas

EBNA1BP2

Probable rRNA-processing protein EBP2

Also known as: EBP2, EBP2_HUMAN, NOBP, P40

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99848
Gene: EBNA1BP2
Ensembl: ENSG00000117395
Chromosome: 1
Canonical length: 306 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Nucleoli rim,Mitotic chromosome

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in rRNA processing and ribosomal large subunit biogenesis. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

306 residues, UniProt reviewed canonical sequence.

>Q99848|EBNA1BP2
     1  MDTPPLSDSE SESDESLVTD RELQDAFSRG LLKPGLNVVL EGPKKAVNDV NGLKQCLAEF
    61  KRDLEWVERL DVTLGPVPEI GGSEAPAPQN KDQKAVDPED DFQREMSFYR QAQAAVLAVL
   121  PRLHQLKVPT KRPTDYFAEM AKSDLQMQKI RQKLQTKQAA MERSEKAKQL RALRKYGKKV
   181  QTEVLQKRQQ EKAHMMNAIK KYQKGFSDKL DFLEGDQKPL AQRKKAGAKG QQMRKGPSAK
   241  RRYKNQKFGF GGKKKGSKWN TRESYDDVSS FRAKTAHGRG LKRPGKKGSN KRPGKRTREK
   301  MKNRTH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EBNA1BP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 124 nTPM

Expression across tissuesHPA

Tissue

liver: 124 nTPM
kidney: 54 nTPM
epididymis: 53 nTPM
cerebral cortex: 51 nTPM
skeletal muscle: 50 nTPM
urinary bladder: 49 nTPM

Single-cell type

hepatocytes: 397 nCPM
proximal tubule cells: 389 nCPM
esophageal basal cells: 210 nCPM
late primary spermatocytes: 209 nCPM
esophageal suprabasal cells: 160 nCPM
migrating cytotrophoblasts: 156 nCPM

Immune cell

naive B-cell: 69 nTPM
myeloid DC: 69 nTPM
plasmacytoid DC: 66 nTPM
memory B-cell: 62 nTPM
T-reg: 61 nTPM
NK-cell: 60 nTPM

Brain region

choroid plexus: 32 nTPM
cerebral cortex: 31 nTPM
hypothalamus: 29 nTPM
basal ganglia: 28 nTPM
white matter: 27 nTPM
medulla oblongata: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.27
DepMap mean gene effect: -0.96
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Eukaryotic rRNA processing
Eukaryotic rRNA processing protein EBP2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EBNA1BP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EBNA1BP2 as an antibody target. Whether an autoantibody or antibody against EBNA1BP2 could matter depends on whether native EBNA1BP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EBNA1BP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EBNA1BP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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