Seroatlas · Human Serome Atlas

PUM3

Pumilio homolog 3

Also known as: HA-8, hPUF-A, KIAA0020, PEN, Puf-A, PUF6, PUM3_HUMAN, XTP5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15397
Gene: PUM3
Ensembl: ENSG00000080608
Chromosome: 9
Canonical length: 648 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in regulation of translation. Located in chromosome; endoplasmic reticulum; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

648 residues, UniProt reviewed canonical sequence.

>Q15397|PUM3
     1  MEVKGKKQFT GKSTKTAQEK NRFHKNSDSG SSKTFPTRKV AKEGGPKVTS RNFEKSITKL
    61  GKKGVKQFKN KQQGDKSPKN KFQPANKFNK KRKFQPDGRS DESAAKKPKW DDFKKKKKEL
   121  KQSRQLSDKT NYDIVVRAKQ MWEILRRKDC DKEKRVKLMS DLQKLIQGKI KTIAFAHDST
   181  RVIQCYIQYG NEEQRKQAFE ELRDDLVELS KAKYSRNIVK KFLMYGSKPQ IAEIIRSFKG
   241  HVRKMLRHAE ASAIVEYAYN DKAILEQRNM LTEELYGNTF QLYKSADHRT LDKVLEVQPE
   301  KLELIMDEMK QILTPMAQKE AVIKHSLVHK VFLDFFTYAP PKLRSEMIEA IREAVVYLAH
   361  THDGARVAMH CLWHGTPKDR KVIVKTMKTY VEKVANGQYS HLVLLAAFDC IDDTKLVKQI
   421  IISEIISSLP SIVNDKYGRK VLLYLLSPRD PAHTVREIIE VLQKGDGNAH SKKDTEVRRR
   481  ELLESISPAL LSYLQEHAQE VVLDKSACVL VSDILGSATG DVQPTMNAIA SLAATGLHPG
   541  GKDGELHIAE HPAGHLVLKW LIEQDKKMKE NGREGCFAKT LVEHVGMKNL KSWASVNRGA
   601  IILSSLLQSC DLEVANKVKA ALKSLIPTLE KTKSTSKGIE ILLEKLST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PUM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

urinary bladder: 29 nTPM
esophagus: 26 nTPM
breast: 23 nTPM
lymph node: 22 nTPM
appendix: 21 nTPM
tonsil: 21 nTPM

Single-cell type

cone photoreceptor cells: 625 nCPM
rod photoreceptor cells: 491 nCPM
proximal tubule cells: 229 nCPM
sertoli cells: 224 nCPM
alveolar cells type 2: 181 nCPM
alveolar cells type 1: 164 nCPM

Immune cell

MAIT T-cell: 26 nTPM
NK-cell: 25 nTPM
memory B-cell: 24 nTPM
naive B-cell: 23 nTPM
naive CD4 T-cell: 21 nTPM
plasmacytoid DC: 21 nTPM

Brain region

cerebellum: 25 nTPM
cerebral cortex: 22 nTPM
white matter: 21 nTPM
amygdala: 21 nTPM
basal ganglia: 20 nTPM
hypothalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.38
gnomAD pLI: 0
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PUM3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PUM3 as an antibody target. Whether an autoantibody or antibody against PUM3 could matter depends on whether native PUM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PUM3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PUM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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