RPL36
Large ribosomal subunit protein eL36
Also known as: DKFZp566B023, L36, RL36_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y3U8
- Gene
- RPL36
- Ensembl
- ENSG00000130255
- Chromosome
- 19
- Canonical length
- 105 aa
- Protein class
- Predicted intracellular proteins, Ribosomal proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L36E family of ribosomal proteins. It is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
105 residues, UniProt reviewed canonical sequence.
>Q9Y3U8|RPL36
1 MALRYPMAVG LNKGHKVTKN VSKPRHSRRR GRLTKHTKFV RDMIREVCGF APYERRAMEL
61 LKVSKDKRAL KFIKKRVGTH IRAKRKREEL SNVLAAMRKA AAKKDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RPL36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.49
- Highest tissue expression
- 2,566 nTPM
Expression across tissuesHPA
Tissue
- ovary: 2,566 nTPM
- pancreas: 2,070 nTPM
- skin: 1,852 nTPM
- adrenal gland: 1,532 nTPM
- esophagus: 1,387 nTPM
- cervix: 1,307 nTPM
Single-cell type
- oocytes: 7,469 nCPM
- decidual stromal cells: 7,403 nCPM
- breast secretory cells: 7,321 nCPM
- suprabasal keratinocytes: 7,010 nCPM
- pancreatic acinar cells: 6,770 nCPM
- ovarian stromal cells: 6,521 nCPM
Immune cell
- total PBMC: 4,677 nTPM
- naive CD4 T-cell: 2,619 nTPM
- memory B-cell: 2,504 nTPM
- naive B-cell: 2,456 nTPM
- memory CD4 T-cell: 2,394 nTPM
- naive CD8 T-cell: 2,251 nTPM
Brain region
- thalamus: 353 nTPM
- hypothalamus: 321 nTPM
- white matter: 311 nTPM
- amygdala: 309 nTPM
- basal ganglia: 306 nTPM
- spinal cord: 299 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.81
- gnomAD pLI
- 0.68
- gnomAD missense Z
- 1.19
- DepMap mean gene effect
- -2.08
- DepMap dependency class
- pan
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RPL36 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RPL36 as an antibody target. Whether an autoantibody or antibody against RPL36 could matter depends on whether native RPL36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RPL36 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RPL36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...