Seroatlas · Human Serome Atlas

MEPCE

7SK snRNA methylphosphate capping enzyme

Also known as: BCDIN3, FLJ20257, MEPCE_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L2J0
Gene: MEPCE
Ensembl: ENSG00000146834
Chromosome: 7
Canonical length: 689 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cell Junctions

OverviewNCBI Gene

Enables 7SK snRNA binding activity and RNA 5'-gamma-phosphate methyltransferase activity. Involved in RNA modification; positive regulation of protein localization to Cajal body; and positive regulation of snRNA transcription by RNA polymerase II. Located in nucleus. Part of 7SK snRNP. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

689 residues, UniProt reviewed canonical sequence.

>Q7L2J0|MEPCE
     1  MIEMAAEKEP FLVPAPPPPL KDESGGGGGP TVPPHQEAAS GELRGGTERG PGRCAPSAGS
    61  PAAAVGRESP GAAATSSSGP QAQQHRGGGP QAQSHGEARL SDPPGRAAPP DVGEERRGGG
   121  GTELGPPAPP RPRNGYQPHR PPGGGGGKRR NSCNVGGGGG GFKHPAFKRR RRVNSDCDSV
   181  LPSNFLLGGN IFDPLNLNSL LDEEVSRTLN AETPKSSPLP AKGRDPVEIL IPKDITDPLS
   241  LNTCTDEGHV VLASPLKTGR KRHRHRGQHH QQQQAAGGSE SHPVPPTAPL TPLLHGEGAS
   301  QQPRHRGQNR DAPQPYELNT AINCRDEVVS PLPSALQGPS GSLSAPPAAS VISAPPSSSS
   361  RHRKRRRTSS KSEAGARGGG QGSKEKGRGS WGGRHHHHHP LPAAGFKKQQ RKFQYGNYCK
   421  YYGYRNPSCE DGRLRVLKPE WFRGRDVLDL GCNVGHLTLS IACKWGPSRM VGLDIDSRLI
   481  HSARQNIRHY LSEELRLPPQ TLEGDPGAEG EEGTTTVRKR SCFPASLTAS RGPIAAPQVP
   541  LDGADTSVFP NNVVFVTGNY VLDRDDLVEA QTPEYDVVLC LSLTKWVHLN WGDEGLKRMF
   601  RRIYRHLRPG GILVLEPQPW SSYGKRKTLT ETIYKNYYRI QLKPEQFSSY LTSPDVGFSS
   661  YELVATPHNT SKGFQRPVYL FHKARSPSH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEPCE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 76 nTPM

Expression across tissuesHPA

Tissue

testis: 76 nTPM
spleen: 54 nTPM
ovary: 40 nTPM
adrenal gland: 40 nTPM
skin: 40 nTPM
parathyroid gland: 39 nTPM

Single-cell type

platelets: 17 nCPM
epididymal basal cells: 14 nCPM
epididymal efferent duct ciliated cells: 11 nCPM
ependymal cells: 9.9 nCPM
renal connecting tubule cells: 8.4 nCPM
epididymal clear cells: 8.2 nCPM

Immune cell

total PBMC: 9.5 nTPM
plasmacytoid DC: 8.3 nTPM
naive B-cell: 8.2 nTPM
memory B-cell: 8.1 nTPM
naive CD4 T-cell: 8.1 nTPM
naive CD8 T-cell: 7.3 nTPM

Brain region

cerebral cortex: 37 nTPM
basal ganglia: 36 nTPM
thalamus: 36 nTPM
white matter: 36 nTPM
medulla oblongata: 35 nTPM
amygdala: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.21
gnomAD pLI: 1
gnomAD missense Z: 1.99
DepMap mean gene effect: -1.06
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of transcription by RNA polymerase II
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of protein localization to Cajal body
positive regulation of snRNA transcription by RNA polymerase II
RNA methylation
snRNA metabolic process
snRNA modification

Molecular functions

7SK snRNA binding
O-methyltransferase activity
RNA binding
RNA methyltransferase activity
S-adenosylmethionine-dependent methyltransferase activity
snRNA binding
RNA 5'-gamma-phosphate methyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MEPCE in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MEPCE as an antibody target. Whether an autoantibody or antibody against MEPCE could matter depends on whether native MEPCE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MEPCE is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MEPCE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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