Seroatlas · Human Serome Atlas

SRP19

Signal recognition particle 19 kDa protein

Also known as: SRP19_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P09132
Gene: SRP19
Ensembl: ENSG00000153037
Chromosome: 5
Canonical length: 144 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Nuclear bodies,Cytosol

OverviewNCBI Gene

Enables 7S RNA binding activity. Contributes to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Located in cytosol; nuclear body; and nucleolus. Part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

144 residues, UniProt reviewed canonical sequence.

>P09132|SRP19
     1  MACAAARSPA DQDRFICIYP AYLNNKKTIA EGRRIPISKA VENPTATEIQ DVCSAVGLNV
    61  FLEKNKMYSR EWNRDVQYRG RVRVQLKQED GSLCLVQFPS RKSVMLYAAE MIPKLKTRTQ
   121  KTGGADQSLQ QGEGSKKGKG KKKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRP19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 75 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 75 nTPM
liver: 46 nTPM
pancreas: 41 nTPM
pituitary gland: 39 nTPM
tonsil: 37 nTPM
thyroid gland: 37 nTPM

Single-cell type

late primary spermatocytes: 231 nCPM
syncytiotrophoblasts: 185 nCPM
esophageal apical cells: 181 nCPM
extravillous trophoblasts: 167 nCPM
epididymal principal cells: 155 nCPM
esophageal suprabasal cells: 150 nCPM

Immune cell

plasmacytoid DC: 87 nTPM
T-reg: 72 nTPM
basophil: 67 nTPM
MAIT T-cell: 61 nTPM
memory CD4 T-cell: 55 nTPM
memory B-cell: 55 nTPM

Brain region

hypothalamus: 28 nTPM
cerebral cortex: 26 nTPM
white matter: 25 nTPM
midbrain: 23 nTPM
hippocampal formation: 23 nTPM
cerebellum: 23 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SRP19.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 37 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0.01
gnomAD missense Z: 0.26
DepMap mean gene effect: -1.64
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Signal recognition particle, SRP19 subunit
Signal recognition particle, subunit SRP19-like superfamily
SRP19 protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRP19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRP19 as an antibody target. Whether an autoantibody or antibody against SRP19 could matter depends on whether native SRP19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRP19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRP19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...