MTDH
Protein LYRIC
Also known as: 3D3, AEG-1, LYRIC, LYRIC_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q86UE4
- Gene
- MTDH
- Ensembl
- ENSG00000147649
- Chromosome
- 8
- Canonical length
- 582 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Endoplasmic reticulum
OverviewNCBI Gene
Enables NF-kappaB binding activity; double-stranded RNA binding activity; and transcription coactivator activity. Involved in several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of intracellular signal transduction; and regulation of DNA-templated transcription. Located in endoplasmic reticulum; nuclear lumen; and perinuclear region of cytoplasm. Implicated in hepatocellular carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
582 residues, UniProt reviewed canonical sequence.
>Q86UE4|MTDH
1 MAARSWQDEL AQQAEEGSAR LREMLSVGLG FLRTELGLDL GLEPKRYPGW VILVGTGALG
61 LLLLFLLGYG WAAACAGARK KRRSPPRKRE EAAAVPAAAP DDLALLKNLR SEEQKKKNRK
121 KLSEKPKPNG RTVEVAEGEA VRTPQSVTAK QPPEIDKKNE KSKKNKKKSK SDAKAVQNSS
181 RHDGKEVDEG AWETKISHRE KRQQRKRDKV LTDSGSLDST IPGIENTITV TTEQLTTASF
241 PVGSKKNKGD SHLNVQVSNF KSGKGDSTLQ VSSGLNENLT VNGGGWNEKS VKLSSQISAG
301 EEKWNSVSPA SAGKRKTEPS AWSQDTGDAN TNGKDWGRSW SDRSIFSGIG STAEPVSQST
361 TSDYQWDVSR NQPYIDDEWS GLNGLSSADP NSDWNAPAEE WGNWVDEERA SLLKSQEPIP
421 DDQKVSDDDK EKGEGALPTG KSKKKKKKKK KQGEDNSTAQ DTEELEKEIR EDLPVNTSKT
481 RPKQEKAFSL KTISTSDPAE VLVKNSQPIK TLPPATSTEP SVILSKSDSD KSSSQVPPIL
541 QETDKSKSNT KQNSVPPSQT KSETSWESPK QIKKKKKARR ETLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MTDH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.69
- Highest tissue expression
- 104 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 104 nTPM
- liver: 84 nTPM
- thymus: 61 nTPM
- thyroid gland: 59 nTPM
- smooth muscle: 58 nTPM
- tonsil: 57 nTPM
Single-cell type
- neutrophil progenitors: 895 nCPM
- plasma cells: 789 nCPM
- monocyte progenitors: 631 nCPM
- hepatocytes: 559 nCPM
- epididymal principal cells: 548 nCPM
- esophageal basal cells: 498 nCPM
Immune cell
- plasmacytoid DC: 113 nTPM
- myeloid DC: 87 nTPM
- memory B-cell: 72 nTPM
- classical monocyte: 72 nTPM
- basophil: 57 nTPM
- non-classical monocyte: 55 nTPM
Brain region
- white matter: 99 nTPM
- medulla oblongata: 86 nTPM
- choroid plexus: 82 nTPM
- cerebellum: 79 nTPM
- spinal cord: 79 nTPM
- basal ganglia: 78 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.43
- gnomAD pLI
- 0.33
- gnomAD missense Z
- 1.01
- DepMap mean gene effect
- -0.12
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- lipopolysaccharide-mediated signaling pathway
- negative regulation of apoptotic process
- negative regulation of transcription by RNA polymerase II
- positive regulation of angiogenesis
- positive regulation of autophagy
- positive regulation of canonical NF-kappaB signal transduction
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- regulation of transcription by RNA polymerase II
Molecular functions
- double-stranded RNA binding
- NF-kappaB binding
- RNA binding
- RNA polymerase II-specific DNA-binding transcription factor binding
- transcription coactivator activity
- transcription coregulator activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Transcriptional Regulators and Tumor Expansion
- Protein LYRIC
- Lysine-rich CEACAM1 co-isolated protein family
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of MTDH in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MTDH as an antibody target. Whether an autoantibody or antibody against MTDH could matter depends on whether native MTDH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MTDH is annotated at the cell surface, where native MTDH is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label MTDH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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