Seroatlas · Human Serome Atlas

NOP2

28S rRNA (cytosine(4447)-C(5))-methyltransferase

Also known as: NOL1, NOP120, NOP2_HUMAN, NSUN1, p120

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P46087
Gene
NOP2
Ensembl
ENSG00000111641
Chromosome
12
Canonical length
812 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoli

OverviewNCBI Gene

Enables rRNA (cytosine-C5-)-methyltransferase activity. Involved in positive regulation of cell population proliferation; regulation of signal transduction by p53 class mediator; and ribosome biogenesis. Located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

812 residues, UniProt reviewed canonical sequence.

>P46087|NOP2
     1  MGRKLDPTKE KRGPGRKARK QKGAETELVR FLPAVSDENS KRLSSRARKR AAKRRLGSVE
    61  APKTNKSPEA KPLPGKLPKG ISAGAVQTAG KKGPQSLFNA PRGKKRPAPG SDEEEEEEDS
   121  EEDGMVNHGD LWGSEDDADT VDDYGADSNS EDEEEGEALL PIERAARKQK AREAAAGIQW
   181  SEEETEDEEE EKEVTPESGP PKVEEADGGL QINVDEEPFV LPPAGEMEQD AQAPDLQRVH
   241  KRIQDIVGIL RDFGAQREEG RSRSEYLNRL KKDLAIYYSY GDFLLGKLMD LFPLSELVEF
   301  LEANEVPRPV TLRTNTLKTR RRDLAQALIN RGVNLDPLGK WSKTGLVVYD SSVPIGATPE
   361  YLAGHYMLQG ASSMLPVMAL APQEHERILD MCCAPGGKTS YMAQLMKNTG VILANDANAE
   421  RLKSVVGNLH RLGVTNTIIS HYDGRQFPKV VGGFDRVLLD APCSGTGVIS KDPAVKTNKD
   481  EKDILRCAHL QKELLLSAID SVNATSKTGG YLVYCTCSIT VEENEWVVDY ALKKRNVRLV
   541  PTGLDFGQEG FTRFRERRFH PSLRSTRRFY PHTHNMDGFF IAKFKKFSNS IPQSQTGNSE
   601  TATPTNVDLP QVIPKSENSS QPAKKAKGAA KTKQQLQKQQ HPKKASFQKL NGISKGADSE
   661  LSTVPSVTKT QASSSFQDSS QPAGKAEGIR EPKVTGKLKQ RSPKLQSSKK VAFLRQNAPP
   721  KGTDTQTPAV LSPSKTQATL KPKDHHQPLG RAKGVEKQQL PEQPFEKAAF QKQNDTPKGP
   781  QPPTVSPIRS SRPPPAKRKK SQSRGNSQLL LS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 37 nTPM
  • bone marrow: 33 nTPM
  • spleen: 29 nTPM
  • tonsil: 27 nTPM
  • lymph node: 26 nTPM
  • esophagus: 26 nTPM

Single-cell type

  • microglia: 13 nCPM
  • brain inhibitory neurons: 11 nCPM
  • astrocytes: 10 nCPM
  • brain excitatory neurons: 10 nCPM
  • other brain neurons: 9.7 nCPM
  • bergmann glia: 8.7 nCPM

Immune cell

  • MAIT T-cell: 33 nTPM
  • myeloid DC: 29 nTPM
  • naive CD8 T-cell: 28 nTPM
  • naive CD4 T-cell: 27 nTPM
  • memory CD8 T-cell: 27 nTPM
  • plasmacytoid DC: 25 nTPM

Brain region

  • cerebral cortex: 16 nTPM
  • thalamus: 12 nTPM
  • white matter: 12 nTPM
  • hypothalamus: 12 nTPM
  • cerebellum: 11 nTPM
  • basal ganglia: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.17
gnomAD pLI
1
gnomAD missense Z
0.64
DepMap mean gene effect
-1.17
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NOP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOP2 as an antibody target. Whether an autoantibody or antibody against NOP2 could matter depends on whether native NOP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NOP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NOP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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