Seroatlas · Human Serome Atlas

EIF3H

Eukaryotic translation initiation factor 3 subunit H

Also known as: eIF3-gamma, eIF3-p40, EIF3H_HUMAN, EIF3S3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15372
Gene
EIF3H
Ensembl
ENSG00000147677
Chromosome
8
Canonical length
352 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Enables metal-dependent deubiquitinase activity. Contributes to translation initiation factor activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process and translational initiation. Located in extracellular exosome and membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in breast cancer; prostate cancer; and prostate carcinoma. Biomarker of prostate cancer. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

352 residues, UniProt reviewed canonical sequence.

>O15372|EIF3H
     1  MASRKEGTGS TATSSSSTAG AAGKGKGKGG SGDSAVKQVQ IDGLVVLKII KHYQEEGQGT
    61  EVVQGVLLGL VVEDRLEITN CFPFPQHTED DADFDEVQYQ MEMMRSLRHV NIDHLHVGWY
   121  QSTYYGSFVT RALLDSQFSY QHAIEESVVL IYDPIKTAQG SLSLKAYRLT PKLMEVCKEK
   181  DFSPEALKKA NITFEYMFEE VPIVIKNSHL INVLMWELEK KSAVADKHEL LSLASSNHLG
   241  KNLQLLMDRV DEMSQDIVKY NTYMRNTSKQ QQQKHQYQQR RQQENMQRQS RGEPPLPEED
   301  LSKLFKPPQP PARMDSLLIA GQINTYCQNI KEFTAQNLGK LFMAQALQEY NN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF3H can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
238 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 238 nTPM
  • ovary: 233 nTPM
  • bone marrow: 220 nTPM
  • tonsil: 217 nTPM
  • lymph node: 195 nTPM
  • thymus: 179 nTPM

Single-cell type

  • esophageal apical cells: 1,459 nCPM
  • esophageal suprabasal cells: 866 nCPM
  • extravillous trophoblasts: 741 nCPM
  • decidual stromal cells: 722 nCPM
  • syncytiotrophoblasts: 704 nCPM
  • esophageal basal cells: 682 nCPM

Immune cell

  • total PBMC: 295 nTPM
  • naive CD4 T-cell: 284 nTPM
  • T-reg: 266 nTPM
  • myeloid DC: 260 nTPM
  • naive CD8 T-cell: 242 nTPM
  • memory B-cell: 227 nTPM

Brain region

  • white matter: 103 nTPM
  • spinal cord: 92 nTPM
  • hypothalamus: 88 nTPM
  • medulla oblongata: 85 nTPM
  • basal ganglia: 84 nTPM
  • cerebellum: 78 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.59
gnomAD pLI
0.05
gnomAD missense Z
0.64
DepMap mean gene effect
-0.94
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 16% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF3H in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF3H as an antibody target. Whether an autoantibody or antibody against EIF3H could matter depends on whether native EIF3H is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF3H is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF3H as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EIF3H. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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