Seroatlas · Human Serome Atlas

SRP72

Signal recognition particle subunit SRP72

Also known as: SRP72_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O76094
Gene: SRP72
Ensembl: ENSG00000174780
Chromosome: 4
Canonical length: 671 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters

OverviewNCBI Gene

This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

671 residues, UniProt reviewed canonical sequence.

>O76094|SRP72
     1  MASGGSGGVS VPALWSEVNR YGQNGDFTRA LKTVNKILQI NKDDVTALHC KVVCLIQNGS
    61  FKEALNVINT HTKVLANNSL SFEKAYCEYR LNRIENALKT IESANQQTDK LKELYGQVLY
   121  RLERYDECLA VYRDLVRNSQ DDYDEERKTN LSAVVAAQSN WEKVVPENLG LQEGTHELCY
   181  NTACALIGQG QLNQAMKILQ KAEDLCRRSL SEDTDGTEED PQAELAIIHG QMAYILQLQG
   241  RTEEALQLYN QIIKLKPTDV GLLAVIANNI ITINKDQNVF DSKKKVKLTN AEGVEFKLSK
   301  KQLQAIEFNK ALLAMYTNQA EQCRKISASL QSQSPEHLLP VLIQAAQLCR EKQHTKAIEL
   361  LQEFSDQHPE NAAEIKLTMA QLKISQGNIS KACLILRSIE ELKHKPGMVS ALVTMYSHEE
   421  DIDSAIEVFT QAIQWYQNHQ PKSPAHLSLI REAANFKLKY GRKKEAISDL QQLWKQNPKD
   481  IHTLAQLISA YSLVDPEKAK ALSKHLPSSD SMSLKVDVEA LENSAGATYI RKKGGKVTGD
   541  SQPKEQGQGD LKKKKKKKKG KLPKNYDPKV TPDPERWLPM RERSYYRGRK KGKKKDQIGK
   601  GTQGATAGAS SELDASKTVS SPPTSPRPGS AATVSASTSN IIPPRHQKPA GAPATKKKQQ
   661  QKKKKGGKGG W

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRP72 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 69 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 69 nTPM
tonsil: 52 nTPM
thyroid gland: 51 nTPM
thymus: 49 nTPM
breast: 47 nTPM
lymph node: 46 nTPM

Single-cell type

extravillous trophoblasts: 292 nCPM
plasma cells: 231 nCPM
syncytiotrophoblasts: 230 nCPM
esophageal suprabasal cells: 204 nCPM
esophageal basal cells: 201 nCPM
migrating cytotrophoblasts: 198 nCPM

Immune cell

myeloid DC: 82 nTPM
intermediate monocyte: 71 nTPM
MAIT T-cell: 65 nTPM
classical monocyte: 65 nTPM
plasmacytoid DC: 62 nTPM
T-reg: 61 nTPM

Brain region

choroid plexus: 57 nTPM
hypothalamus: 54 nTPM
midbrain: 54 nTPM
white matter: 51 nTPM
pons: 50 nTPM
spinal cord: 48 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SRP72.

Disease | AllUniProt

Conditions SRP72 is implicated in, by any mechanism.

Bone marrow failure syndrome 1 (BMFS1) MIM:614675

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0
gnomAD missense Z: 1.02
DepMap mean gene effect: -1.06
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

SRP-dependent cotranslational protein targeting to membrane

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tetratricopeptide-like helical domain superfamily
Tetratricopeptide repeat
Tetratricopeptide repeat
Signal recognition particle, SRP72 subunit, RNA-binding
Signal recognition particle, SRP72 subunit
Signal recognition particle subunit SRP72, TPR-like repeat
SRP72 RNA-binding domain
Putative TPR-like repeat

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRP72 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRP72 as an antibody target. Whether an autoantibody or antibody against SRP72 could matter depends on whether native SRP72 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRP72 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRP72 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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