Seroatlas · Human Serome Atlas

RPL13A

Large ribosomal subunit protein uL13

Also known as: L13A, RL13A_HUMAN, TSTA1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P40429
Gene
RPL13A
Ensembl
ENSG00000142541
Chromosome
19
Canonical length
203 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nucleoli,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L13P family of ribosomal proteins that is a component of the 60S subunit. The encoded protein also plays a role in the repression of inflammatory genes as a component of the IFN-gamma-activated inhibitor of translation (GAIT) complex. This gene is co-transcribed with the small nucleolar RNA genes U32, U33, U34, and U35, which are located in the second, fourth, fifth, and sixth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

203 residues, UniProt reviewed canonical sequence.

>P40429|RPL13A
     1  MAEVQVLVLD GRGHLLGRLA AIVAKQVLLG RKVVVVRCEG INISGNFYRN KLKYLAFLRK
    61  RMNTNPSRGP YHFRAPSRIF WRTVRGMLPH KTKRGQAALD RLKVFDGIPP PYDKKKRMVV
   121  PAALKVVRLK PTRKFAYLGR LAHEVGWKYQ AVTATLEEKR KEKAKIHYRK KKQLMRLRKQ
   181  AEKNVEKKID KYTEVLKTHG LLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL13A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
4,574 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 4,574 nTPM
  • pancreas: 4,235 nTPM
  • skin: 3,310 nTPM
  • bone marrow: 2,978 nTPM
  • lymph node: 2,803 nTPM
  • cervix: 2,790 nTPM

Single-cell type

  • decidual stromal cells: 15,621 nCPM
  • esophageal suprabasal cells: 15,608 nCPM
  • esophageal basal cells: 14,661 nCPM
  • ovarian stromal cells: 12,103 nCPM
  • extravillous trophoblasts: 12,039 nCPM
  • esophageal apical cells: 11,776 nCPM

Immune cell

  • total PBMC: 13,507 nTPM
  • memory B-cell: 8,540 nTPM
  • naive B-cell: 8,023 nTPM
  • naive CD4 T-cell: 7,319 nTPM
  • memory CD4 T-cell: 6,270 nTPM
  • naive CD8 T-cell: 5,950 nTPM

Brain region

  • choroid plexus: 581 nTPM
  • spinal cord: 556 nTPM
  • thalamus: 544 nTPM
  • basal ganglia: 521 nTPM
  • medulla oblongata: 521 nTPM
  • white matter: 500 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.83
gnomAD missense Z
0.32
DepMap mean gene effect
-1.9
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL13A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL13A as an antibody target. Whether an autoantibody or antibody against RPL13A could matter depends on whether native RPL13A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL13A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL13A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL13A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...