Seroatlas · Human Serome Atlas

PRKRA

Interferon-inducible double-stranded RNA-dependent protein kinase activator A

Also known as: DYT16, HSD14, PACT, PRKRA_HUMAN, RAX

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75569
Gene
PRKRA
Ensembl
ENSG00000180228
Chromosome
2
Canonical length
313 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>O75569|PRKRA
     1  MSQSRHRAEA PPLEREDSGT FSLGKMITAK PGKTPIQVLH EYGMKTKNIP VYECERSDVQ
    61  IHVPTFTFRV TVGDITCTGE GTSKKLAKHR AAEAAINILK ANASICFAVP DPLMPDPSKQ
   121  PKNQLNPIGS LQELAIHHGW RLPEYTLSQE GGPAHKREYT TICRLESFME TGKGASKKQA
   181  KRNAAEKFLA KFSNISPENH ISLTNVVGHS LGCTWHSLRN SPGEKINLLK RSLLSIPNTD
   241  YIQLLSEIAK EQGFNITYLD IDELSANGQY QCLAELSTSP ITVCHGSGIS CGNAQSDAAH
   301  NALQYLKIIA ERK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRKRA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
95 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 95 nTPM
  • tongue: 68 nTPM
  • blood vessel: 45 nTPM
  • heart muscle: 33 nTPM
  • spinal cord: 32 nTPM
  • colon: 31 nTPM

Single-cell type

  • late spermatids: 456 nCPM
  • oocytes: 189 nCPM
  • late primary spermatocytes: 167 nCPM
  • rod photoreceptor cells: 147 nCPM
  • choroid plexus epithelial cells: 142 nCPM
  • early spermatids: 128 nCPM

Immune cell

  • plasmacytoid DC: 50 nTPM
  • T-reg: 38 nTPM
  • myeloid DC: 37 nTPM
  • memory B-cell: 35 nTPM
  • naive CD4 T-cell: 32 nTPM
  • total PBMC: 31 nTPM

Brain region

  • white matter: 20 nTPM
  • spinal cord: 16 nTPM
  • choroid plexus: 16 nTPM
  • medulla oblongata: 15 nTPM
  • hypothalamus: 14 nTPM
  • cerebellum: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRKRA.

Disease | AllUniProt

Conditions PRKRA is implicated in, by any mechanism.

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 222 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Dystonia 16
  • PRKRA-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0.42
gnomAD missense Z
1.58
DepMap mean gene effect
-0.69
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRKRA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRKRA as an antibody target. Whether an autoantibody or antibody against PRKRA could matter depends on whether native PRKRA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRKRA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRKRA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRKRA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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