Seroatlas · Human Serome Atlas

MPHOSPH10

U3 small nucleolar ribonucleoprotein protein MPP10

Also known as: CT90, MPP10, MPP10_HUMAN, MPP10P, PPP1R106

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00566
Gene: MPHOSPH10
Ensembl: ENSG00000124383
Chromosome: 2
Canonical length: 681 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoli,Nucleoli rim,Mitotic chromosome

OverviewNCBI Gene

This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein associates with the U3 small nucleolar ribonucleoprotein 60-80S complexes and may be involved in pre-rRNA processing. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

681 residues, UniProt reviewed canonical sequence.

>O00566|MPHOSPH10
     1  MAPQVWRRRT LERCLTEVGK ATGRPECFLT IQEGLASKFT SLTKVLYDFN KILENGRIHG
    61  SPLQKLVIEN FDDEQIWQQL ELQNEPILQY FQNAVSETIN DEDISLLPES EEQEREEDGS
   121  EIEADDKEDL EDLEEEEVSD MGNDDPEMGE RAENSSKSDL RKSPVFSDED SDLDFDISKL
   181  EQQSKVQNKG QGKPREKSIV DDKFFKLSEM EAYLENIEKE EERKDDNDEE EEDIDFFEDI
   241  DSDEDEGGLF GSKKLKSGKS SRNLKYKDFF DPVESDEDIT NVHDDELDSN KEDDEIAEEE
   301  AEELSISETD EDDDLQENED NKQHKESLKR VTFALPDDAE TEDTGVLNVK KNSDEVKSSF
   361  EKRQEKMNEK IASLEKELLE KKPWQLQGEV TAQKRPENSL LEETLHFDHA VRMAPVITEE
   421  TTLQLEDIIK QRIRDQAWDD VVRKEKPKED AYEYKKRLTL DHEKSKLSLA EIYEQEYIKL
   481  NQQKTAEEEN PEHVEIQKMM DSLFLKLDAL SNFHFIPKPP VPEIKVVSNL PAITMEEVAP
   541  VSVSDAALLA PEEIKEKNKA GDIKTAAEKT ATDKKRERRK KKYQKRMKIK EKEKRRKLLE
   601  KSSVDQAGKY SKTVASEKLK QLTKTGKASF IKDEGKDKAL KSSQAFFSKL QDQVKMQIND
   661  AKKTEKKKKK RQDISVHKLK L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MPHOSPH10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 36 nTPM
esophagus: 29 nTPM
liver: 28 nTPM
tonsil: 25 nTPM
skin: 25 nTPM
bone marrow: 24 nTPM

Single-cell type

esophageal suprabasal cells: 129 nCPM
esophageal apical cells: 113 nCPM
differentiating spermatogonia: 100 nCPM
early primary spermatocytes: 100 nCPM
erythrocyte progenitors: 95 nCPM
esophageal basal cells: 94 nCPM

Immune cell

non-classical monocyte: 21 nTPM
naive CD4 T-cell: 19 nTPM
naive CD8 T-cell: 18 nTPM
MAIT T-cell: 18 nTPM
memory CD4 T-cell: 17 nTPM
basophil: 16 nTPM

Brain region

cerebellum: 18 nTPM
hypothalamus: 18 nTPM
cerebral cortex: 18 nTPM
white matter: 17 nTPM
midbrain: 17 nTPM
pons: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.36
gnomAD pLI: 0.85
gnomAD missense Z: 0.54
DepMap mean gene effect: -1.14
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

U3 small nucleolar ribonucleoprotein complex, subunit Mpp10
Mpp10 protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MPHOSPH10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MPHOSPH10 as an antibody target. Whether an autoantibody or antibody against MPHOSPH10 could matter depends on whether native MPHOSPH10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MPHOSPH10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MPHOSPH10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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