Seroatlas · Human Serome Atlas

TMCC1

Transmembrane and coiled-coil domains protein 1

Also known as: KIAA0779, TMCC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O94876
Gene
TMCC1
Ensembl
ENSG00000172765
Chromosome
3
Canonical length
653 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables identical protein binding activity. Involved in several processes, including endosome fission; endosome membrane tubulation; and membrane fission. Located in cytosol; endoplasmic reticulum-endosome membrane contact site; and rough endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

653 residues, UniProt reviewed canonical sequence.

>O94876|TMCC1
     1  MEPSGSEQLF EDPDPGGKSQ DAEARKQTES EQKLSKMTHN ALENINVIGQ GLKHLFQHQR
    61  RRSSVSPHDV QQIQADPEPE MDLESQNACA EIDGVPTHPT ALNRVLQQIR VPPKMKRGTS
   121  LHSRRGKPEA PKGSPQINRK SGQEMTAVMQ SGRPRSSSTT DAPTSSAMME IACAAAAAAA
   181  ACLPGEEGTA ERIERLEVSS LAQTSSAVAS STDGSIHTDS VDGTPDPQRT KAAIAHLQQK
   241  ILKLTEQIKI AQTARDDNVA EYLKLANSAD KQQAARIKQV FEKKNQKSAQ TILQLQKKLE
   301  HYHRKLREVE QNGIPRQPKD VFRDMHQGLK DVGAKVTGFS EGVVDSVKGG FSSFSQATHS
   361  AAGAVVSKPR EIASLIRNKF GSADNIPNLK DSLEEGQVDD AGKALGVISN FQSSPKYGSE
   421  EDCSSATSGS VGANSTTGGI AVGASSSKTN TLDMQSSGFD ALLHEIQEIR ETQARLEESF
   481  ETLKEHYQRD YSLIMQTLQE ERYRCERLEE QLNDLTELHQ NEILNLKQEL ASMEEKIAYQ
   541  SYERARDIQE ALEACQTRIS KMELQQQQQQ VVQLEGLENA TARNLLGKLI NILLAVMAVL
   601  LVFVSTVANC VVPLMKTRNR TFSTLFLVVF IAFLWKHWDA LFSYVERFFS SPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMCC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • liver: 33 nTPM
  • skeletal muscle: 29 nTPM
  • tongue: 20 nTPM
  • retina: 14 nTPM
  • cerebellum: 13 nTPM
  • testis: 13 nTPM

Single-cell type

  • neutrophils: 1,257 nCPM
  • myonuclei: 780 nCPM
  • prostatic glandular cells: 417 nCPM
  • renal collecting duct intercalated cells: 392 nCPM
  • distal convoluted tubule cells: 391 nCPM
  • gonadotrophs: 389 nCPM

Immune cell

  • neutrophil: 11 nTPM
  • non-classical monocyte: 2.2 nTPM
  • eosinophil: 2.1 nTPM
  • T-reg: 1.9 nTPM
  • plasmacytoid DC: 1.6 nTPM
  • naive CD8 T-cell: 1.5 nTPM

Brain region

  • cerebellum: 77 nTPM
  • thalamus: 64 nTPM
  • cerebral cortex: 57 nTPM
  • midbrain: 55 nTPM
  • white matter: 55 nTPM
  • amygdala: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.85
gnomAD missense Z
3.06
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMCC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMCC1 as an antibody target. Whether an autoantibody or antibody against TMCC1 could matter depends on whether native TMCC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMCC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMCC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMCC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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