Seroatlas · Human Serome Atlas

CCDC137

Coiled-coil domain-containing protein 137

Also known as: CC137_HUMAN, MGC16597

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PK04
Gene: CCDC137
Ensembl: ENSG00000185298
Chromosome: 17
Canonical length: 289 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Mitotic chromosome

OverviewNCBI Gene

Enables RNA binding activity. Located in chromosome; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

289 residues, UniProt reviewed canonical sequence.

>Q6PK04|CCDC137
     1  MAGAGRGAAV SRVQAGPGSP RRARGRQQVQ PLGKQRPAPW PGLRSKEKKK VNCKPKNQDE
    61  QEIPFRLREI MRSRQEMKNP ISNKKRKKAA QVTFRKTLEK EAKGEEPDIA VPKFKQRKGE
   121  SDGAYIHRMQ QEAQHVLFLS KNQAIRQPEV QAAPKEKSEQ KKAKKAFQKR RLDKVRRKKE
   181  EKAADRLEQE LLRDTVKFGE VVLQPPELTA RPQRSVSKDQ PGRRSQMLRM LLSPGGVSQP
   241  LTASLARQRI VEEERERAVQ AYRALKQRQQ QLHGERPHLT SRKKPEPQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC137 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

esophagus: 31 nTPM
skin: 26 nTPM
spleen: 19 nTPM
vagina: 18 nTPM
cervix: 17 nTPM
bone marrow: 17 nTPM

Single-cell type

differentiating spermatogonia: 108 nCPM
esophageal basal cells: 93 nCPM
esophageal suprabasal cells: 73 nCPM
early primary spermatocytes: 58 nCPM
erythrocyte progenitors: 56 nCPM
megakaryocyte progenitors: 55 nCPM

Immune cell

naive B-cell: 13 nTPM
NK-cell: 13 nTPM
plasmacytoid DC: 13 nTPM
non-classical monocyte: 12 nTPM
eosinophil: 12 nTPM
gdT-cell: 12 nTPM

Brain region

pons: 14 nTPM
thalamus: 14 nTPM
choroid plexus: 13 nTPM
midbrain: 13 nTPM
cerebral cortex: 13 nTPM
medulla oblongata: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: -0.58
DepMap mean gene effect: -0.4
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 137

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC137 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC137 as an antibody target. Whether an autoantibody or antibody against CCDC137 could matter depends on whether native CCDC137 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC137 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC137 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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