Seroatlas · Human Serome Atlas

MRPS26

Small ribosomal subunit protein mS26

Also known as: C20orf193, dJ534B8.3, MRP-S13, MRP-S26, RPMS13, RT26_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BYN8
Gene: MRPS26
Ensembl: ENSG00000125901
Chromosome: 20
Canonical length: 205 aa
Protein class: Predicted intracellular proteins, Ribosomal proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. This gene lies adjacent to and downstream of the gonadotropin-releasing hormone precursor gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>Q9BYN8|MRPS26
     1  MLRALSRLGA GTPCRPRAPL VLPARGRKTR HDPLAKSKIE RVNMPPAVDP AEFFVLMERY
    61  QHYRQTVRAL RMEFVSEVQR KVHEARAGVL AERKALKDAA EHRELMAWNQ AENRRLHELR
   121  IARLRQEERE QEQRQALEQA RKAEEVQAWA QRKEREVLQL QEEVKNFITR ENLEARVEAA
   181  LDSRKNYNWA ITREGLVVRP QRRDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPS26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 114 nTPM

Expression across tissuesHPA

Tissue

liver: 114 nTPM
kidney: 77 nTPM
adrenal gland: 75 nTPM
heart muscle: 75 nTPM
cerebral cortex: 74 nTPM
hypothalamus: 74 nTPM

Single-cell type

esophageal basal cells: 244 nCPM
cytotrophoblasts: 224 nCPM
migrating cytotrophoblasts: 200 nCPM
oocytes: 175 nCPM
epididymal efferent duct absorptive cells: 162 nCPM
esophageal suprabasal cells: 153 nCPM

Immune cell

memory B-cell: 115 nTPM
naive B-cell: 105 nTPM
NK-cell: 97 nTPM
MAIT T-cell: 88 nTPM
myeloid DC: 88 nTPM
naive CD4 T-cell: 88 nTPM

Brain region

hypothalamus: 57 nTPM
medulla oblongata: 56 nTPM
choroid plexus: 55 nTPM
cerebellum: 54 nTPM
pons: 53 nTPM
thalamus: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: 0.48
DepMap mean gene effect: -0.41
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrial translation

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Small ribosomal subunit protein mS26
Mitochondrial ribosome subunit S26

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPS26 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPS26 as an antibody target. Whether an autoantibody or antibody against MRPS26 could matter depends on whether native MRPS26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPS26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPS26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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