Seroatlas · Human Serome Atlas

KNOP1

Lysine-rich nucleolar protein 1

Also known as: 101F10.1, C16orf88, FAM191A, KNOP1_HUMAN, TSG118

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q1ED39
Gene
KNOP1
Ensembl
ENSG00000103550
Chromosome
16
Canonical length
458 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli,Nucleoli rim,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a nucleolar protein that interacts with zinc finger 106 protein. The encoded protein has several of the same characteristics as nucleostemin and may be involved in testis development. [provided by RefSeq, Feb 2017]

Canonical amino-acid sequenceUniProt

458 residues, UniProt reviewed canonical sequence.

>Q1ED39|KNOP1
     1  MITKTHKVDL GLPEKKKKKK VVKEPETRYS VLNNDDYFAD VSPLRATSPS KSVAHGQAPE
    61  MPLVKKKKKK KKGVSTLCEE HVEPETTLPA RRTEKSPSLR KQVFGHLEFL SGEKKNKKSP
   121  LAMSHASGVK TSPDPRQGEE ETRVGKKLKK HKKEKKGAQD PTAFSVQDPW FCEAREARDV
   181  GDTCSVGKKD EEQAALGQKR KRKSPREHNG KVKKKKKIHQ EGDALPGHSK PSRSMESSPR
   241  KGSKKKPVKV EAPEYIPISD DPKASAKKKM KSKKKVEQPV IEEPALKRKK KKKRKESGVA
   301  GDPWKEETDT DLEVVLEKKG NMDEAHIDQV RRKALQEEID RESGKTEASE TRKWTGTQFG
   361  QWDTAGFENE DQKLKFLRLM GGFKNLSPSF SRPASTIARP NMALGKKAAD SLQQNLQRDY
   421  DRAMSWKYSR GAGLGFSTAP NKIFYIDRNA SKSVKLED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KNOP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • midbrain: 17 nTPM
  • spinal cord: 15 nTPM
  • hippocampal formation: 15 nTPM
  • basal ganglia: 15 nTPM
  • skeletal muscle: 14 nTPM
  • parathyroid gland: 13 nTPM

Single-cell type

  • oligodendrocytes: 189 nCPM
  • differentiating spermatogonia: 165 nCPM
  • astrocytes: 122 nCPM
  • early primary spermatocytes: 103 nCPM
  • paneth cells: 81 nCPM
  • leydig cells: 79 nCPM

Immune cell

  • naive CD4 T-cell: 10 nTPM
  • naive B-cell: 7.2 nTPM
  • intermediate monocyte: 7.1 nTPM
  • non-classical monocyte: 6.7 nTPM
  • MAIT T-cell: 5.9 nTPM
  • memory B-cell: 5.8 nTPM

Brain region

  • white matter: 36 nTPM
  • pons: 26 nTPM
  • basal ganglia: 25 nTPM
  • medulla oblongata: 23 nTPM
  • midbrain: 23 nTPM
  • cerebral cortex: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.25
gnomAD pLI
0
gnomAD missense Z
0.13
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KNOP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KNOP1 as an antibody target. Whether an autoantibody or antibody against KNOP1 could matter depends on whether native KNOP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KNOP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KNOP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KNOP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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