Seroatlas · Human Serome Atlas

MRPS27

Small ribosomal subunit protein mS27

Also known as: KIAA0264, RT27_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92552
Gene
MRPS27
Ensembl
ENSG00000113048
Chromosome
5
Canonical length
414 aa
Protein class
Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nucleoli,Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that may be a functional partner of the death associated protein 3 (DAP3). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013]

Canonical amino-acid sequenceUniProt

414 residues, UniProt reviewed canonical sequence.

>Q92552|MRPS27
     1  MAASIVRRGM LLARQVVLPQ LSPAGKRYLL SSAYVDSHKW EAREKEHYCL ADLASLMDKT
    61  FERKLPVSSL TISRLIDNIS SREEIDHAEY YLYKFRHSPN CWYLRNWTIH TWIRQCLKYD
   121  AQDKALYTLV NKVQYGIFPD NFTFNLLMDS FIKKENYKDA LSVVFEVMMQ EAFEVPSTQL
   181  LSLYVLFHCL AKKTDFSWEE ERNFGASLLL PGLKQKNSVG FSSQLYGYAL LGKVELQQGL
   241  RAVYHNMPLI WKPGYLDRAL QVMEKVAASP EDIKLCREAL DVLGAVLKAL TSADGASEEQ
   301  SQNDEDNQGS EKLVEQLDIE ETEQSKLPQY LERFKALHSK LQALGKIESE GLLSLTTQLV
   361  KEKLSTCEAE DIATYEQNLQ QWHLDLVQLI QREQQQREQA KQEYQAQKAA KASA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPS27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
80 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 80 nTPM
  • skeletal muscle: 56 nTPM
  • heart muscle: 50 nTPM
  • choroid plexus: 38 nTPM
  • liver: 36 nTPM
  • tonsil: 36 nTPM

Single-cell type

  • choroid plexus epithelial cells: 133 nCPM
  • erythrocyte progenitors: 96 nCPM
  • epididymal principal cells: 89 nCPM
  • megakaryocyte progenitors: 86 nCPM
  • megakaryocyte-erythroid progenitors: 86 nCPM
  • esophageal basal cells: 84 nCPM

Immune cell

  • myeloid DC: 42 nTPM
  • NK-cell: 37 nTPM
  • naive CD8 T-cell: 35 nTPM
  • T-reg: 31 nTPM
  • MAIT T-cell: 31 nTPM
  • memory B-cell: 30 nTPM

Brain region

  • choroid plexus: 33 nTPM
  • cerebral cortex: 24 nTPM
  • basal ganglia: 22 nTPM
  • white matter: 22 nTPM
  • spinal cord: 21 nTPM
  • thalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.87
gnomAD pLI
0
gnomAD missense Z
0.02
DepMap mean gene effect
-0.52
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPS27 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPS27 as an antibody target. Whether an autoantibody or antibody against MRPS27 could matter depends on whether native MRPS27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPS27 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPS27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRPS27. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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