IMP4
U3 small nucleolar ribonucleoprotein protein IMP4
Also known as: BXDC4, IMP4_HUMAN, MGC19606
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96G21
- Gene
- IMP4
- Ensembl
- ENSG00000136718
- Chromosome
- 2
- Canonical length
- 291 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoli
OverviewNCBI Gene
The protein encoded by this gene, along with IMP3 and MPP10, is part of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. This complex is necessary for the early cleavage steps of pre-18S ribosomal RNA processing. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Canonical amino-acid sequenceUniProt
291 residues, UniProt reviewed canonical sequence.
>Q96G21|IMP4
1 MLRREARLRR EYLYRKAREE AQRSAQERKE RLRRALEENR LIPTELRREA LALQGSLEFD
61 DAGGEGVTSH VDDEYRWAGV EDPKVMITTS RDPSSRLKMF AKELKLVFPG AQRMNRGRHE
121 VGALVRACKA NGVTDLLVVH EHRGTPVGLI VSHLPFGPTA YFTLCNVVMR HDIPDLGTMS
181 EAKPHLITHG FSSRLGKRVS DILRYLFPVP KDDSHRVITF ANQDDYISFR HHVYKKTDHR
241 NVELTEVGPR FELKLYMIRL GTLEQEATAD VEWRWHPYTN TARKRVFLST ELocalizationUniProt · AlphaFold · HPA
Whether an antibody against IMP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 84 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 84 nTPM
- pancreas: 66 nTPM
- liver: 63 nTPM
- heart muscle: 49 nTPM
- stomach: 37 nTPM
- blood vessel: 36 nTPM
Single-cell type
- esophageal basal cells: 143 nCPM
- pancreatic acinar cells: 132 nCPM
- extravillous trophoblasts: 113 nCPM
- late spermatids: 108 nCPM
- migrating cytotrophoblasts: 106 nCPM
- hepatocytes: 101 nCPM
Immune cell
- memory B-cell: 116 nTPM
- naive B-cell: 100 nTPM
- plasmacytoid DC: 92 nTPM
- NK-cell: 91 nTPM
- total PBMC: 89 nTPM
- myeloid DC: 84 nTPM
Brain region
- midbrain: 39 nTPM
- medulla oblongata: 38 nTPM
- thalamus: 38 nTPM
- hypothalamus: 34 nTPM
- pons: 34 nTPM
- cerebral cortex: 34 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.95
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.36
- DepMap mean gene effect
- -0.98
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of IMP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IMP4 as an antibody target. Whether an autoantibody or antibody against IMP4 could matter depends on whether native IMP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IMP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label IMP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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