Seroatlas · Human Serome Atlas

MRPS10

Small ribosomal subunit protein uS10m

Also known as: FLJ10567, RT10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P82664
Gene: MRPS10
Ensembl: ENSG00000048544
Chromosome: 6
Canonical length: 201 aa
Protein class: Predicted intracellular proteins, Ribosomal proteins
Subcellular location: Actin filaments,Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S10P family. Pseudogenes corresponding to this gene are found on chromosomes 1q, 3p, and 9p. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>P82664|MRPS10
     1  MAARTAFGAV CRRLWQGLGN FSVNTSKGNT AKNGGLLLST NMKWVQFSNL HVDVPKDLTK
    61  PVVTISDEPD ILYKRLSVLV KGHDKAVLDS YEYFAVLAAK ELGISIKVHE PPRKIERFTL
   121  LQSVHIYKKH RVQYEMRTLY RCLELEHLTG STADVYLEYI QRNLPEGVAM EVTKTQLEQL
   181  PEHIKEPIWE TLSEEKEESK S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPS10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 69 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 69 nTPM
tongue: 58 nTPM
heart muscle: 44 nTPM
esophagus: 42 nTPM
liver: 35 nTPM
kidney: 27 nTPM

Single-cell type

esophageal apical cells: 621 nCPM
esophageal suprabasal cells: 193 nCPM
megakaryocytes: 167 nCPM
cytotrophoblasts: 124 nCPM
esophageal basal cells: 123 nCPM
ocular epithelial cells: 113 nCPM

Immune cell

plasmacytoid DC: 38 nTPM
T-reg: 35 nTPM
intermediate monocyte: 30 nTPM
memory B-cell: 30 nTPM
NK-cell: 30 nTPM
naive CD4 T-cell: 30 nTPM

Brain region

white matter: 25 nTPM
hypothalamus: 25 nTPM
cerebral cortex: 24 nTPM
midbrain: 24 nTPM
basal ganglia: 23 nTPM
pons: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.73
gnomAD pLI: 0
gnomAD missense Z: -0.36
DepMap mean gene effect: -0.56
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrial translation

Cellular components

Protein domainsUniProt · Pfam · InterPro

Small ribosomal subunit protein uS10 domain
Small ribosomal subunit protein uS10 domain superfamily
Ribosomal protein S10p/S20e
Small ribosomal subunit protein uS10m

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPS10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPS10 as an antibody target. Whether an autoantibody or antibody against MRPS10 could matter depends on whether native MRPS10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPS10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPS10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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