Seroatlas · Human Serome Atlas

KRR1

KRR1 small subunit processome component homolog

Also known as: HRB2, KRR1_HUMAN, RIP-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13601
Gene
KRR1
Ensembl
ENSG00000111615
Chromosome
12
Canonical length
381 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Nucleoli rim,Mitotic chromosome

OverviewNCBI Gene

Enables RNA binding activity. Involved in ribosomal small subunit biogenesis. Located in chromosome; intercellular bridge; and nuclear lumen. Part of small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

381 residues, UniProt reviewed canonical sequence.

>Q13601|KRR1
     1  MASPSLERPE KGAGKSEFRN QKPKPENQDE SELLTVPDGW KEPAFSKEDN PRGLLEESSF
    61  ATLFPKYREA YLKECWPLVQ KALNEHHVNA TLDLIEGSMT VCTTKKTFDP YIIIRARDLI
   121  KLLARSVSFE QAVRILQDDV ACDIIKIGSL VRNKERFVKR RQRLIGPKGS TLKALELLTN
   181  CYIMVQGNTV SAIGPFSGLK EVRKVVLDTM KNIHPIYNIK SLMIKRELAK DSELRSQSWE
   241  RFLPQFKHKN VNKRKEPKKK TVKKEYTPFP PPQPESQIDK ELASGEYFLK ANQKKRQKME
   301  AIKAKQAEAI SKRQEERNKA FIPPKEKPIV KPKEASTETK IDVASIKEKV KKAKNKKLGA
   361  LTAEEIALKM EADEKKKKKK K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 41 nTPM
  • skeletal muscle: 22 nTPM
  • tongue: 21 nTPM
  • liver: 19 nTPM
  • parathyroid gland: 19 nTPM
  • salivary gland: 18 nTPM

Single-cell type

  • oocytes: 198 nCPM
  • erythrocyte progenitors: 129 nCPM
  • urothelial cells: 120 nCPM
  • megakaryocytes: 118 nCPM
  • thymic myoid cells: 117 nCPM
  • esophageal apical cells: 107 nCPM

Immune cell

  • memory B-cell: 23 nTPM
  • naive B-cell: 21 nTPM
  • naive CD4 T-cell: 19 nTPM
  • memory CD4 T-cell: 18 nTPM
  • T-reg: 18 nTPM
  • naive CD8 T-cell: 18 nTPM

Brain region

  • cerebellum: 15 nTPM
  • hypothalamus: 13 nTPM
  • white matter: 12 nTPM
  • cerebral cortex: 11 nTPM
  • choroid plexus: 11 nTPM
  • spinal cord: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0
gnomAD missense Z
0.52
DepMap mean gene effect
-1.09
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • K Homology domain
  • K Homology domain, type 1 superfamily
  • Ribosomal RNA assembly KRR1
  • KRR1 small subunit processome component, first KH domain
  • KRR1 small subunit processome component, second KH domain
  • KRR1 small subunit processome component, second KH domain, eukaryotes
  • KRR1 small subunit processome component, first KH domain, eukaryotes
  • Krr1 KH1 domain
  • KRR1 small subunit processome component, second KH domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KRR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRR1 as an antibody target. Whether an autoantibody or antibody against KRR1 could matter depends on whether native KRR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KRR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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