Seroatlas · Human Serome Atlas

CHLSN

Protein cholesin

Also known as: C7orf50, CHOLN_HUMAN, MGC11257, YCR016W

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRJ6
Gene: CHLSN
Ensembl: ENSG00000146540
Chromosome: 7
Canonical length: 194 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables hormone activity. Involved in negative regulation of cholesterol biosynthetic process. Is active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

194 residues, UniProt reviewed canonical sequence.

>Q9BRJ6|CHLSN
     1  MAKQKRKVPE VTEKKNKKLK KASAEGPLLG PEAAPSGEGA GSKGEAVLRP GLDAEPELSP
    61  EEQRVLERKL KKERKKEERQ RLREAGLVAQ HPPARRSGAE LALDYLCRWA QKHKNWRFQK
   121  TRQTWLLLHM YDSDKVPDEH FSTLLAYLEG LQGRARELTV QKAEALMREL DEEGSDPPLP
   181  GRAQRIRQVL QLLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHLSN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 146 nTPM

Expression across tissuesHPA

Tissue

amygdala: 146 nTPM
pituitary gland: 136 nTPM
cerebral cortex: 123 nTPM
hippocampal formation: 108 nTPM
basal ganglia: 107 nTPM
pancreas: 103 nTPM

Single-cell type

hofbauer cells: 244 nCPM
epididymal principal cells: 183 nCPM
somatotrophs: 169 nCPM
corticotrophs: 147 nCPM
esophageal suprabasal cells: 142 nCPM
gonadotrophs: 141 nCPM

Immune cell

eosinophil: 402 nTPM
myeloid DC: 209 nTPM
naive B-cell: 166 nTPM
intermediate monocyte: 137 nTPM
non-classical monocyte: 135 nTPM
classical monocyte: 130 nTPM

Brain region

thalamus: 79 nTPM
amygdala: 76 nTPM
medulla oblongata: 75 nTPM
cerebral cortex: 68 nTPM
basal ganglia: 68 nTPM
spinal cord: 62 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of cholesterol biosynthetic process

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

WKF domain
WKF domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHLSN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHLSN as an antibody target. Whether an autoantibody or antibody against CHLSN could matter depends on whether native CHLSN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHLSN is annotated as secreted, so native CHLSN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CHLSN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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