Seroatlas · Human Serome Atlas

LTV1

Protein LTV1 homolog

Also known as: C6orf93, dJ468K18.4, FLJ14909, LTV1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96GA3
Gene
LTV1
Ensembl
ENSG00000135521
Chromosome
6
Canonical length
475 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be involved in ribosomal small subunit biogenesis and ribosomal small subunit export from nucleus. Located in cytosol and nucleoplasm. Implicated in inflammatory poikiloderma with hair abnormalities and acral keratoses. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

475 residues, UniProt reviewed canonical sequence.

>Q96GA3|LTV1
     1  MPHRKKKPFI EKKKAVSFHL VHRSQRDPLA ADESAPQRVL LPTQKIDNEE RRAEQRKYGV
    61  FFDDDYDYLQ HLKEPSGPSE LIPSSTFSAH NRREEKEETL VIPSTGIKLP SSVFASEFEE
   121  DVGLLNKAAP VSGPRLDFDP DIVAALDDDF DFDDPDNLLE DDFILQANKA TGEEEGMDIQ
   181  KSENEDDSEW EDVDDEKGDS NDDYDSAGLL SDEDCMSVPG KTHRAIADHL FWSEETKSRF
   241  TEYSMTSSVM RRNEQLTLHD ERFEKFYEQY DDDEIGALDN AELEGSIQVD SNRLQEVLND
   301  YYKEKAENCV KLNTLEPLED QDLPMNELDE SEEEEMITVV LEEAKEKWDC ESICSTYSNL
   361  YNHPQLIKYQ PKPKQIRISS KTGIPLNVLP KKGLTAKQTE RIQMINGSDL PKVSTQPRSK
   421  NESKEDKRAR KQAIKEERKE RRVEKKANKL AFKLEKRRQE KELLNLKKNV EGLKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LTV1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
50 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 50 nTPM
  • skeletal muscle: 35 nTPM
  • skin: 28 nTPM
  • adipose tissue: 25 nTPM
  • lymph node: 25 nTPM
  • tonsil: 24 nTPM

Single-cell type

  • oocytes: 51 nCPM
  • differentiating spermatogonia: 43 nCPM
  • early primary spermatocytes: 33 nCPM
  • erythrocyte progenitors: 33 nCPM
  • megakaryocyte progenitors: 27 nCPM
  • megakaryocyte-erythroid progenitors: 23 nCPM

Immune cell

  • NK-cell: 36 nTPM
  • plasmacytoid DC: 31 nTPM
  • memory B-cell: 29 nTPM
  • myeloid DC: 25 nTPM
  • naive CD8 T-cell: 25 nTPM
  • naive B-cell: 25 nTPM

Brain region

  • white matter: 16 nTPM
  • hypothalamus: 15 nTPM
  • cerebral cortex: 15 nTPM
  • thalamus: 15 nTPM
  • cerebellum: 14 nTPM
  • basal ganglia: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LTV1.

Disease | AllUniProt

Conditions LTV1 is implicated in, by any mechanism.

  • Inflammatory poikiloderma with hair abnormalities and acral keratoses (IPHAK) MIM:620199

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 80 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Inflammatory poikiloderma with hair abnormalities and acral keratoses

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.87
gnomAD pLI
0
gnomAD missense Z
0.44
DepMap mean gene effect
-1.04
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Low temperature viability protein Ltv1
  • Low temperature viability protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LTV1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LTV1 as an antibody target. Whether an autoantibody or antibody against LTV1 could matter depends on whether native LTV1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LTV1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LTV1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LTV1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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