Seroatlas · Human Serome Atlas

AATF

Protein AATF

Also known as: AATF_HUMAN, BFR2, CHE-1, CHE1, DED

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NY61
Gene: AATF
Ensembl: ENSG00000275700
Chromosome: 17
Canonical length: 560 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

560 residues, UniProt reviewed canonical sequence.

>Q9NY61|AATF
     1  MAGPQPLALQ LEQLLNPRPS EADPEADPEE ATAARVIDRF DEGEDGEGDF LVVGSIRKLA
    61  SASLLDTDKR YCGKTTSRKA WNEDHWEQTL PGSSDEEISD EEGSGDEDSE GLGLEEYDED
   121  DLGAAEEQEC GDHRESKKSR SHSAKTPGFS VQSISDFEKF TKGMDDLGSS EEEEDEESGM
   181  EEGDDAEDSQ GESEEDRAGD RNSEDDGVVM TFSSVKVSEE VEKGRAVKNQ IALWDQLLEG
   241  RIKLQKALLT TNQLPQPDVF PLFKDKGGPE FSSALKNSHK ALKALLRSLV GLQEELLFQY
   301  PDTRYLVDGT KPNAGSEEIS SEDDELVEEK KQQRRRVPAK RKLEMEDYPS FMAKRFADFT
   361  VYRNRTLQKW HDKTKLASGK LGKGFGAFER SILTQIDHIL MDKERLLRRT QTKRSVYRVL
   421  GKPEPAAQPV PESLPGEPEI LPQAPANAHL KDLDEEIFDD DDFYHQLLRE LIERKTSSLD
   481  PNDQVAMGRQ WLAIQKLRSK IHKKVDRKAS KGRKLRFHVL SKLLSFMAPI DHTTMNDDAR
   541  TELYRSLFGQ LHPPDEGHGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AATF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 37 nTPM
blood vessel: 37 nTPM
tonsil: 37 nTPM
thymus: 33 nTPM
bone marrow: 33 nTPM
skin: 33 nTPM

Single-cell type

renal connecting tubule cells: 108 nCPM
syncytiotrophoblasts: 103 nCPM
oocytes: 92 nCPM
proximal tubule cells: 89 nCPM
distal convoluted tubule cells: 82 nCPM
choroid plexus epithelial cells: 80 nCPM

Immune cell

eosinophil: 90 nTPM
non-classical monocyte: 78 nTPM
T-reg: 76 nTPM
intermediate monocyte: 74 nTPM
neutrophil: 68 nTPM
memory CD8 T-cell: 64 nTPM

Brain region

white matter: 25 nTPM
basal ganglia: 23 nTPM
medulla oblongata: 21 nTPM
thalamus: 19 nTPM
cerebellum: 19 nTPM
midbrain: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: 0.3
DepMap mean gene effect: -0.87
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Apoptosis-antagonizing transcription factor, C-terminal
AATF leucine zipper-containing domain
Protein AATF/Bfr2
Apoptosis-antagonizing transcription factor, C-terminal
Apoptosis antagonizing transcription factor

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AATF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AATF as an antibody target. Whether an autoantibody or antibody against AATF could matter depends on whether native AATF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AATF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AATF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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