Seroatlas · Human Serome Atlas

IPO7

Importin-7

Also known as: Imp7, IPO7_HUMAN, RANBP7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95373
Gene: IPO7
Ensembl: ENSG00000205339
Chromosome: 11
Canonical length: 1038 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1038 residues, UniProt reviewed canonical sequence.

>O95373|IPO7
     1  MDPNTIIEAL RGTMDPALRE AAERQLNEAH KSLNFVSTLL QITMSEQLDL PVRQAGVIYL
    61  KNMITQYWPD RETAPGDISP YTIPEEDRHC IRENIVEAII HSPELIRVQL TTCIHHIIKH
   121  DYPSRWTAIV DKIGFYLQSD NSACWLGILL CLYQLVKNYE YKKPEERSPL VAAMQHFLPV
   181  LKDRFIQLLS DQSDQSVLIQ KQIFKIFYAL VQYTLPLELI NQQNLTEWIE ILKTVVNRDV
   241  PNETLQVEED DRPELPWWKC KKWALHILAR LFERYGSPGN VSKEYNEFAE VFLKAFAVGV
   301  QQVLLKVLYQ YKEKQYMAPR VLQQTLNYIN QGVSHALTWK NLKPHIQGII QDVIFPLMCY
   361  TDADEELWQE DPYEYIRMKF DVFEDFISPT TAAQTLLFTA CSKRKEVLQK TMGFCYQILT
   421  EPNADPRKKD GALHMIGSLA EILLKKKIYK DQMEYMLQNH VFPLFSSELG YMRARACWVL
   481  HYFCEVKFKS DQNLQTALEL TRRCLIDDRE MPVKVEAAIA LQVLISNQEK AKEYITPFIR
   541  PVMQALLHII RETENDDLTN VIQKMICEYS EEVTPIAVEM TQHLAMTFNQ VIQTGPDEEG
   601  SDDKAVTAMG ILNTIDTLLS VVEDHKEITQ QLEGICLQVI GTVLQQHVLE FYEEIFSLAH
   661  SLTCQQVSPQ MWQLLPLVFE VFQQDGFDYF TDMMPLLHNY VTVDTDTLLS DTKYLEMIYS
   721  MCKKVLTGVA GEDAECHAAK LLEVIILQCK GRGIDQCIPL FVEAALERLT REVKTSELRT
   781  MCLQVAIAAL YYNPHLLLNT LENLRFPNNV EPVTNHFITQ WLNDVDCFLG LHDRKMCVLG
   841  LCALIDMEQI PQVLNQVSGQ ILPAFILLFN GLKRAYACHA EHENDSDDDD EAEDDDETEE
   901  LGSDEDDIDE DGQEYLEILA KQAGEDGDDE DWEEDDAEET ALEGYSTIID DEDNPVDEYQ
   961  IFKAIFQTIQ NRNPVWYQAL THGLNEEQRK QLQDIATLAD QRRAAHESKM IEKHGGYKFS
  1021  APVVPSSFNF GGPAPGMN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IPO7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 104 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 104 nTPM
tongue: 87 nTPM
thyroid gland: 51 nTPM
urinary bladder: 48 nTPM
heart muscle: 47 nTPM
retina: 44 nTPM

Single-cell type

alveolar cells type 1: 230 nCPM
basal keratinocytes: 227 nCPM
alveolar cells type 2: 210 nCPM
suprabasal keratinocytes: 207 nCPM
ocular epithelial cells: 202 nCPM
pancreatic acinar cells: 187 nCPM

Immune cell

non-classical monocyte: 3.8 nTPM
NK-cell: 3.5 nTPM
myeloid DC: 3.2 nTPM
MAIT T-cell: 2.8 nTPM
intermediate monocyte: 2.6 nTPM
memory CD8 T-cell: 2 nTPM

Brain region

white matter: 68 nTPM
medulla oblongata: 66 nTPM
hypothalamus: 66 nTPM
cerebellum: 65 nTPM
midbrain: 65 nTPM
spinal cord: 65 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.11
gnomAD pLI: 1
gnomAD missense Z: 3.53
DepMap mean gene effect: -1.05
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IPO7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IPO7 as an antibody target. Whether an autoantibody or antibody against IPO7 could matter depends on whether native IPO7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IPO7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IPO7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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