Seroatlas · Human Serome Atlas

MRPS9

Small ribosomal subunit protein uS9m

Also known as: MRP-S9, RPMS9, RT09_HUMAN, S9mt

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P82933
Gene: MRPS9
Ensembl: ENSG00000135972
Chromosome: 2
Canonical length: 396 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

396 residues, UniProt reviewed canonical sequence.

>P82933|MRPS9
     1  MAAPCVSYGG AVSYRLLLWG RGSLARKQGL WKTAAPELQT NVRSQILRLR HTAFVIPKKN
    61  VPTSKRETYT EDFIKKQIEE FNIGKRHLAN MMGEDPETFT QEDIDRAIAY LFPSGLFEKR
   121  ARPVMKHPEQ IFPRQRAIQW GEDGRPFHYL FYTGKQSYYS LMHDVYGMLL NLEKHQSHLQ
   181  AKSLLPEKTV TRDVIGSRWL IKEELEEMLV EKLSDLDYMQ FIRLLEKLLT SQCGAAEEEF
   241  VQRFRRSVTL ESKKQLIEPV QYDEQGMAFS KSEGKRKTAK AEAIVYKHGS GRIKVNGIDY
   301  QLYFPITQDR EQLMFPFHFV DRLGKHDVTC TVSGGGRSAQ AGAIRLAMAK ALCSFVTEDE
   361  VEWMRQAGLL TTDPRVRERK KPGQEGARRK FTWKKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPS9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 92 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 92 nTPM
tongue: 91 nTPM
heart muscle: 63 nTPM
choroid plexus: 40 nTPM
adrenal gland: 34 nTPM
testis: 31 nTPM

Single-cell type

late primary spermatocytes: 219 nCPM
adrenal cortex cells: 99 nCPM
myonuclei: 99 nCPM
erythrocyte progenitors: 98 nCPM
esophageal basal cells: 82 nCPM
thymic myoid cells: 79 nCPM

Immune cell

T-reg: 50 nTPM
NK-cell: 46 nTPM
memory B-cell: 45 nTPM
MAIT T-cell: 43 nTPM
memory CD4 T-cell: 43 nTPM
myeloid DC: 43 nTPM

Brain region

choroid plexus: 23 nTPM
white matter: 21 nTPM
cerebral cortex: 20 nTPM
pons: 20 nTPM
cerebellum: 20 nTPM
medulla oblongata: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0.21
DepMap mean gene effect: -0.3
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrial translation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Small ribosomal subunit protein uS9
Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
Ribosomal protein uS5 domain 2-type superfamily
Small ribosomal subunit protein uS9, conserved site
Ribosomal protein S9/S16
Small ribosomal subunit protein uS9, bacteria/plastid

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPS9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPS9 as an antibody target. Whether an autoantibody or antibody against MRPS9 could matter depends on whether native MRPS9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPS9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPS9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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