Seroatlas · Human Serome Atlas

IMP3

U3 small nucleolar ribonucleoprotein protein IMP3

Also known as: BRMS2, C15orf12, FLJ10968, IMP3_HUMAN, MRPS4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NV31
Gene: IMP3
Ensembl: ENSG00000177971
Chromosome: 15
Canonical length: 184 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts with the U3 snoRNP complex. The protein contains an S4 domain. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

184 residues, UniProt reviewed canonical sequence.

>Q9NV31|IMP3
     1  MVRKLKFHEQ KLLKQVDFLN WEVTDHNLHE LRVLRRYRLQ RREDYTRYNQ LSRAVRELAR
    61  RLRDLPERDQ FRVRASAALL DKLYALGLVP TRGSLELCDF VTASSFCRRR LPTVLLKLRM
   121  AQHLQAAVAF VEQGHVRVGP DVVTDPAFLV TRSMEDFVTW VDSSKIKRHV LEYNEERDDF
   181  DLEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IMP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 95 nTPM

Expression across tissuesHPA

Tissue

liver: 95 nTPM
choroid plexus: 93 nTPM
esophagus: 84 nTPM
skeletal muscle: 75 nTPM
skin: 75 nTPM
spleen: 66 nTPM

Single-cell type

esophageal apical cells: 353 nCPM
esophageal suprabasal cells: 260 nCPM
esophageal basal cells: 229 nCPM
suprabasal keratinocytes: 198 nCPM
basal keratinocytes: 172 nCPM
migrating cytotrophoblasts: 133 nCPM

Immune cell

total PBMC: 210 nTPM
naive CD4 T-cell: 164 nTPM
MAIT T-cell: 162 nTPM
naive CD8 T-cell: 157 nTPM
memory B-cell: 157 nTPM
T-reg: 154 nTPM

Brain region

choroid plexus: 55 nTPM
hypothalamus: 43 nTPM
white matter: 42 nTPM
spinal cord: 39 nTPM
cerebral cortex: 38 nTPM
pons: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.97
gnomAD pLI: 0
gnomAD missense Z: -0.77
DepMap mean gene effect: -1.27
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IMP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IMP3 as an antibody target. Whether an autoantibody or antibody against IMP3 could matter depends on whether native IMP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IMP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IMP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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