MRPS15

Protein identityUniProt · HPA

UniProt accession

P82914

Gene

MRPS15

Ensembl

ENSG00000116898

Chromosome

1

Canonical length

257 aa

Protein class

Predicted intracellular proteins, Ribosomal proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S15P family. The encoded protein is more than two times the size of its E. coli counterpart, with the 12S rRNA binding sites conserved. Between human and mouse, the encoded protein is the least conserved among small subunit ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 15q and 19q. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

257 residues, UniProt reviewed canonical sequence.

>P82914|MRPS15
     1  MLRVAWRTLS LIRTRAVTQV LVPGLPGGGS AKFPFNQWGL QPRSLLLQAA RGYVVRKPAQ
    61  SRLDDDPPPS TLLKDYQNVP GIEKVDDVVK RLLSLEMANK KEMLKIKQEQ FMKKIVANPE
   121  DTRSLEARII ALSVKIRSYE EHLEKHRKDK AHKRYLLMSI DQRKKMLKNL RNTNYDVFEK
   181  ICWGLGIEYT FPPLYYRRAH RRFVTKKALC IRVFQETQKL KKRRRALKAA AAAQKQAKRR
   241  NPDSPAKAIP KTLKDSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPS15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.5

Highest tissue expression

269 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.43

gnomAD pLI

0

gnomAD missense Z

0.35

DepMap mean gene effect

-0.35

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• mitochondrial translation
• translation

Molecular functions

• RNA binding
• structural constituent of ribosome

Cellular components

• mitochondrial inner membrane
• mitochondrial matrix
• mitochondrial small ribosomal subunit
• mitochondrion
• nucleolus
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Small ribosomal subunit protein uS15
• uS15/NS1, RNA-binding domain superfamily
• Ribosomal protein S15
• Small ribosomal subunit protein uS15, bacteria
• Universal small ribosomal subunit uS15

KeywordsUniProt

• Mitochondrion
• Ribonucleoprotein
• Ribosomal protein
• Transit peptide

InteractionsUniProt · HPA

Protein binding partners of MRPS15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• METTL17
• AURKAIP1
• MRPS26
• PTCD3
• RPS6