Seroatlas · Human Serome Atlas

TMCC3

Transmembrane and coiled-coil domain protein 3

Also known as: KIAA1145, TMCC3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULS5
Gene: TMCC3
Ensembl: ENSG00000057704
Chromosome: 12
Canonical length: 477 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Endoplasmic reticulum,Vesicles
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables 14-3-3 protein binding activity and identical protein binding activity. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

477 residues, UniProt reviewed canonical sequence.

>Q9ULS5|TMCC3
     1  MPGSDTALTV DRTYSYPGRH HRCKSRVERH DMNTLSLPLN IRRGGSDTNL NFDVPDGILD
    61  FHKVKLTADS LKQKILKVTE QIKIEQTSRD GNVAEYLKLV NNADKQQAGR IKQVFEKKNQ
   121  KSAHSIAQLQ KKLEQYHRKL REIEQNGASR SSKDISKDHL KDIHRSLKDA HVKSRTAPHC
   181  MESSKSGMPG VSLTPPVFVF NKSREFANLI RNKFGSADNI AHLKNSLEEF RPEASARAYG
   241  GSATIVNKPK YGSDDECSSG TSGSADSNGN QSFGAGGAST LDSQGKLAVI LEELREIKDT
   301  QAQLAEDIEA LKVQFKREYG FISQTLQEER YRYERLEDQL HDLTDLHQHE TANLKQELAS
   361  IEEKVAYQAY ERSRDIQEAL ESCQTRISKL ELHQQEQQAL QTDTVNAKVL LGRCINVILA
   421  FMTVILVCVS TIAKFVSPMM KSRCHILGTF FAVTLLAIFC KNWDHILCAI ERMIIPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMCC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

colon: 21 nTPM
spinal cord: 20 nTPM
small intestine: 20 nTPM
skeletal muscle: 17 nTPM
placenta: 17 nTPM
midbrain: 16 nTPM

Single-cell type

neutrophils: 1,848 nCPM
ocular epithelial cells: 625 nCPM
enterocytes: 421 nCPM
epididymal basal cells: 415 nCPM
colonocytes: 253 nCPM
podocytes: 238 nCPM

Immune cell

neutrophil: 70 nTPM
eosinophil: 47 nTPM
basophil: 17 nTPM
non-classical monocyte: 7.8 nTPM
intermediate monocyte: 6 nTPM
memory B-cell: 5.4 nTPM

Brain region

white matter: 75 nTPM
medulla oblongata: 58 nTPM
midbrain: 57 nTPM
basal ganglia: 55 nTPM
thalamus: 54 nTPM
pons: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
gnomAD missense Z: 0.92
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMCC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMCC3 as an antibody target. Whether an autoantibody or antibody against TMCC3 could matter depends on whether native TMCC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMCC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMCC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...