Seroatlas · Human Serome Atlas

RIOK3

Serine/threonine-protein kinase RIO3

Also known as: RIOK3_HUMAN, SUDD

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14730
Gene: RIOK3
Ensembl: ENSG00000101782
Chromosome: 18
Canonical length: 519 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Plasma membrane,Centriolar satellite,Cytosol

OverviewNCBI Gene

This gene was first identified by the similarity of its product to the Aspergillus nidulans SUDD protein. This gene is now recognized as a member of the right open reading frame (RIO) kinase gene family. This gene encodes a serine/threonine kinase that localizes to the cytoplasm and plays a role in the processing of the pre-40 S ribosomal subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

519 residues, UniProt reviewed canonical sequence.

>O14730|RIOK3
     1  MDLVGVASPE PGTAAAWGPS KCPWAIPQNT ISCSLADVMS EQLAKELQLE EEAAVFPEVA
    61  VAEGPFITGE NIDTSSDLML AQMLQMEYDR EYDAQLRREE KKFNGDSKVS ISFENYRKVH
   121  PYEDSDSSED EVDWQDTRDD PYRPAKPVPT PKKGFIGKGK DITTKHDEVV CGRKNTARME
   181  NFAPEFQVGD GIGMDLKLSN HVFNALKQHA YSEERRSARL HEKKEHSTAE KAVDPKTRLL
   241  MYKMVNSGML ETITGCISTG KESVVFHAYG GSMEDEKEDS KVIPTECAIK VFKTTLNEFK
   301  NRDKYIKDDF RFKDRFSKLN PRKIIRMWAE KEMHNLARMQ RAGIPCPTVV LLKKHILVMS
   361  FIGHDQVPAP KLKEVKLNSE EMKEAYYQTL HLMRQLYHEC TLVHADLSEY NMLWHAGKVW
   421  LIDVSQSVEP THPHGLEFLF RDCRNVSQFF QKGGVKEALS ERELFNAVSG LNITADNEAD
   481  FLAEIEALEK MNEDHVQKNG RKAASFLKDD GDPPLLYDE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIOK3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 165 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 165 nTPM
skeletal muscle: 63 nTPM
esophagus: 62 nTPM
small intestine: 59 nTPM
liver: 52 nTPM
duodenum: 49 nTPM

Single-cell type

esophageal apical cells: 1,542 nCPM
platelets: 1,068 nCPM
neutrophil progenitors: 788 nCPM
ocular epithelial cells: 638 nCPM
neutrophils: 609 nCPM
enterocytes: 540 nCPM

Immune cell

basophil: 50 nTPM
non-classical monocyte: 39 nTPM
intermediate monocyte: 35 nTPM
classical monocyte: 25 nTPM
total PBMC: 21 nTPM
T-reg: 19 nTPM

Brain region

white matter: 25 nTPM
medulla oblongata: 24 nTPM
pons: 21 nTPM
choroid plexus: 21 nTPM
cerebellum: 20 nTPM
cerebral cortex: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0
gnomAD missense Z: 1.06
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RIOK3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIOK3 as an antibody target. Whether an autoantibody or antibody against RIOK3 could matter depends on whether native RIOK3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIOK3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RIOK3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...