Seroatlas · Human Serome Atlas

NOP56

Nucleolar protein 56

Also known as: NOL5A, NOP56_HUMAN, SCA36

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00567
Gene
NOP56
Ensembl
ENSG00000101361
Chromosome
20
Canonical length
594 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoli fibrillar center

OverviewNCBI Gene

Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Expansion of a GGCCTG repeat from 3-8 copies to 1500-2500 copies in an intron of this gene results in spinocerebellar ataxia 36. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them has not been determined. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

594 residues, UniProt reviewed canonical sequence.

>O00567|NOP56
     1  MVLLHVLFEH AVGYALLALK EVEEISLLQP QVEESVLNLG KFHSIVRLVA FCPFASSQVA
    61  LENANAVSEG VVHEDLRLLL ETHLPSKKKK VLLGVGDPKI GAAIQEELGY NCQTGGVIAE
   121  ILRGVRLHFH NLVKGLTDLS ACKAQLGLGH SYSRAKVKFN VNRVDNMIIQ SISLLDQLDK
   181  DINTFSMRVR EWYGYHFPEL VKIINDNATY CRLAQFIGNR RELNEDKLEK LEELTMDGAK
   241  AKAILDASRS SMGMDISAID LINIESFSSR VVSLSEYRQS LHTYLRSKMS QVAPSLSALI
   301  GEAVGARLIA HAGSLTNLAK YPASTVQILG AEKALFRALK TRGNTPKYGL IFHSTFIGRA
   361  AAKNKGRISR YLANKCSIAS RIDCFSEVPT SVFGEKLREQ VEERLSFYET GEIPRKNLDV
   421  MKEAMVQAEE AAAEITRKLE KQEKKRLKKE KKRLAALALA SSENSSSTPE ECEEMSEKPK
   481  KKKKQKPQEV PQENGMEDPS ISFSKPKKKK SFSKEELMSS DLEETAGSTS IPKRKKSTPK
   541  EETVNDPEEA GHRSGSKKKR KFSKEEPVSS GPEEAVGKSS SKKKKKFHKA SQED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOP56 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
60 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 60 nTPM
  • skeletal muscle: 59 nTPM
  • tonsil: 58 nTPM
  • bone marrow: 57 nTPM
  • adipose tissue: 51 nTPM
  • spleen: 50 nTPM

Single-cell type

  • oocytes: 304 nCPM
  • differentiating spermatogonia: 232 nCPM
  • esophageal basal cells: 196 nCPM
  • erythrocyte progenitors: 167 nCPM
  • migrating cytotrophoblasts: 148 nCPM
  • gastric progenitor cells: 141 nCPM

Immune cell

  • MAIT T-cell: 41 nTPM
  • plasmacytoid DC: 41 nTPM
  • memory CD8 T-cell: 37 nTPM
  • memory CD4 T-cell: 36 nTPM
  • memory B-cell: 36 nTPM
  • naive CD4 T-cell: 34 nTPM

Brain region

  • hypothalamus: 46 nTPM
  • pons: 43 nTPM
  • white matter: 43 nTPM
  • cerebral cortex: 41 nTPM
  • hippocampal formation: 37 nTPM
  • midbrain: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NOP56.

Disease | AllUniProt

Conditions NOP56 is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 131 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Spinocerebellar ataxia type 36

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.4
gnomAD pLI
0.62
gnomAD missense Z
0.6
DepMap mean gene effect
-1.35
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NOP56 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOP56 as an antibody target. Whether an autoantibody or antibody against NOP56 could matter depends on whether native NOP56 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOP56 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NOP56 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NOP56. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...