Seroatlas · Human Serome Atlas

PDCD2

Programmed cell death protein 2

Also known as: PDCD2_HUMAN, RP8, ZMYND7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16342
Gene
PDCD2
Ensembl
ENSG00000071994
Chromosome
6
Canonical length
344 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytokinetic bridge

OverviewNCBI Gene

This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

344 residues, UniProt reviewed canonical sequence.

>Q16342|PDCD2
     1  MAAAGARPVE LGFAESAPAW RLRSEQFPSK VGGRPAWLGA AGLPGPQALA CELCGRPLSF
    61  LLQVYAPLPG RPDAFHRCIF LFCCREQPCC AGLRVFRNQL PRKNDFYSYE PPSENPPPET
   121  GESVCLQLKS GAHLCRVCGC LGPKTCSRCH KAYYCSKEHQ TLDWRLGHKQ ACAQPDHLDH
   181  IIPDHNFLFP EFEIVIETED EIMPEVVEKE DYSEIIGSMG EALEEELDSM AKHESREDKI
   241  FQKFKTQIAL EPEQILRYGR GIAPIWISGE NIPQEKDIPD CPCGAKRILE FQVMPQLLNY
   301  LKADRLGKSI DWGILAVFTC AESCSLGTGY TEEFVWKQDV TDTP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDCD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
47 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 47 nTPM
  • pancreas: 43 nTPM
  • lymph node: 40 nTPM
  • breast: 40 nTPM
  • thymus: 39 nTPM
  • epididymis: 38 nTPM

Single-cell type

  • esophageal basal cells: 138 nCPM
  • esophageal suprabasal cells: 133 nCPM
  • esophageal apical cells: 113 nCPM
  • gastric progenitor cells: 101 nCPM
  • differentiating spermatogonia: 101 nCPM
  • breast lactating cells: 90 nCPM

Immune cell

  • T-reg: 20 nTPM
  • NK-cell: 19 nTPM
  • myeloid DC: 17 nTPM
  • MAIT T-cell: 17 nTPM
  • memory CD4 T-cell: 16 nTPM
  • plasmacytoid DC: 16 nTPM

Brain region

  • cerebellum: 17 nTPM
  • hypothalamus: 17 nTPM
  • midbrain: 17 nTPM
  • cerebral cortex: 16 nTPM
  • medulla oblongata: 16 nTPM
  • pons: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.37
gnomAD pLI
0
gnomAD missense Z
0.05
DepMap mean gene effect
-1.21
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDCD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDCD2 as an antibody target. Whether an autoantibody or antibody against PDCD2 could matter depends on whether native PDCD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDCD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDCD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PDCD2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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