Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
IPR014721
Definition
Domain 2 of the small ribosomal subunit protein uS5, previously known as ribosomal protein S5, has a left-handed β-α-β fold that is found in numerous RNA/DNA-binding proteins, as well as in kinases from the GHMP kinase family. Proteins containing this β-α-β fold domain include: Translational machinery components (ribosomal proteins S5 and S9, and domain IV of elongation factors EF-G and eEF-2) PMID:8722013. Ribonuclease P protein (RNase P) PMID:17081993. DNA modification proteins (DNA mismatch repair proteins MutL and PMS2, DNA gyrase B, DNA topoisomerase II, IV-B and VI-B) PMID:11574484. GHMP kinases that transfer a phosphoryl group from ATP to an acceptor (galactokinase ([ec:2.7.1.6]), homoserine kinase ([ec:2.7.1.39]), and mevalonate kinase ([ec:2.7.1.36])) [[cite:PMID:15544330], [cite:PMID:11188689]]. Caenorhabditis elegans early switch protein Xol-1 (a divergent member of the GHMP kinase family that has lost the ATP-binding site) PMID:12672694.
21 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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