Seroatlas · Human Serome Atlas

RPL17

Large ribosomal subunit protein uL22

Also known as: L17, RL17_HUMAN, rpL23

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P18621
Gene
RPL17
Ensembl
ENSG00000265681
Chromosome
18
Canonical length
184 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL23 because the encoded protein shares amino acid identity with ribosomal protein L23 from Halobacterium marismortui; however, its official symbol is RPL17. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream C18orf32 (chromosome 18 open reading frame 32) gene. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

184 residues, UniProt reviewed canonical sequence.

>P18621|RPL17
     1  MVRYSLDPEN PTKSCKSRGS NLRVHFKNTR ETAQAIKGMH IRKATKYLKD VTLQKQCVPF
    61  RRYNGGVGRC AQAKQWGWTQ GRWPKKSAEF LLHMLKNAES NAELKGLDVD SLVIEHIQVN
   121  KAPKMRRRTY RAHGRINPYM SSPCHIEMIL TEKEQIVPKP EEEVAQKKKI SQKKLKKQKL
   181  MARE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
4,817 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 4,817 nTPM
  • pancreas: 4,454 nTPM
  • breast: 2,755 nTPM
  • bone marrow: 2,729 nTPM
  • skin: 2,545 nTPM
  • cervix: 2,445 nTPM

Single-cell type

  • gastric chief cells: 874 nCPM
  • enteric stem cells: 726 nCPM
  • epididymal efferent duct absorptive cells: 660 nCPM
  • epididymal basal cells: 624 nCPM
  • enteric transient amplifying cells: 612 nCPM
  • mucous neck cells: 572 nCPM

Immune cell

  • total PBMC: 2,558 nTPM
  • MAIT T-cell: 2,163 nTPM
  • naive CD4 T-cell: 2,007 nTPM
  • memory B-cell: 1,980 nTPM
  • memory CD4 T-cell: 1,838 nTPM
  • naive CD8 T-cell: 1,774 nTPM

Brain region

  • spinal cord: 396 nTPM
  • white matter: 371 nTPM
  • choroid plexus: 370 nTPM
  • cerebellum: 355 nTPM
  • hypothalamus: 352 nTPM
  • medulla oblongata: 335 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPL17.

Disease | AllUniProt

Conditions RPL17 is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 14 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.92
gnomAD missense Z
1.34
DepMap mean gene effect
-3.07
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL17 as an antibody target. Whether an autoantibody or antibody against RPL17 could matter depends on whether native RPL17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL17. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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